Restoring Glycocalyx Thickness in Older Adults to Improve Vascular Function

Inclusion Criteria: * Age 60-85 years * Able to undergo cardiovascular testing procedures including fasting overnight and holding selected morning medication doses. * Ability to understand and willingness to sign a written informed consent document. * Ability to lie comfortably for up to 90 minutes * Women only: Post-menopausal Exclusion Criteria: * Current or history of CVD disease (heart attack, stroke, heart failure, cardiomyopathy or peripheral artery disease, heart angioplasty/stent or bypass surgery, valve replacement, carotid endarterectomy, heart transplant. * Medical history of stroke or other neurological disorder or systemic illness that could potentially affect cognition or brain function (outside of a diagnosis of MCI, Alzheimer's Disease) or could affect their safety or comfort while undergoing the imaging or cardiovascular studies. * Subjects with evidence of cardiovascular disease at baseline or during the exercise test (evidence of myocardial infarction, abnormal cardiac arrhythmia, myocardial ischemia, conduction delays, \>1mm ST segment depression or elevation; \>3 beat ventricular tachycardia; atrial fibrillation) will be excluded from the study. * Wilson's disease, hemochromatosis * Individuals taking clonidine or other short-acting beta blocker * Resting blood pressure \> 149 mmHg systolic and/or 99mmHg diastolic * BMI \> 40 kg/m2 * Medical history of chronic major psychiatric or current diagnosis of major psychiatric disease (other than dementia). * Unable to provide informed consent due to cognitive impairment * Current clinically abnormal thyroid function not adequately regulated by thyroid hormone supplementation or medication. * Allergic to olives, artichokes, grapes or melons * Current tobacco user or history of tobacco use within the past 3 months (cigarettes, cigars, chewing tobacco, hookah, electronic cigarettes) or living with someone who smokes/has smoked in the past 3 months. * Current diagnosis of diabetes (Type I or insulin dependent Type II) * Current diagnosis of COPD, cystic fibrosis, emphysema, chronic bronchitis * History of renal failure, dialysis or kidney transplant * Current diagnosis or history of liver disease or HIV/AIDS, or cancer requiring chemotherapy or radiation. * Current diagnosis or history of rheumatoid arthritis, systemic lupus erythematosus, Wegener's granuomatosis * Vulnerable populations (prisoners, etc) will not be eligible. * Unwillingness to wash out from a vitamin or dietary supplement regime prior to enrollment and maintain throughout the duration of the study. * Inability to comply with experimental instructions. * Uncontrolled intercurrent illness that would limit compliance with study requirements per investigator. * Inability to fast or hold morning medications doses until after testing is complete. * Hormone replacement use within the past 6 months * Currently enrolled in another study using an study medication, supplement, device or intervention. * Initiation of a new prescription medication or change in dose/frequency in the past three months. Individuals will be become eligible after the medication/dose/frequency has been stable for 3 months.