The Anti-fungal Effect of Miconazol Versus Miconazol-Loaded Chitosan Nanoparticles

Yasmine gamil80 enrolled

Overview

Objective: this study aimed to evaluate the therapeutic effects of topical application of miconazole and miconazole-loaded chitosan nanoparticles in treatment diabetic patients with oral candidiasis.

Abstract: Objective: this study aimed to evaluate the therapeutic effects of topical application of miconazole and miconazole-loaded chitosan nanoparticles in treatment diabetic patients with oral candidiasis. Subjective and methods: In this randomized controlled clinical trial,. A total of 80 diabetic patients presenting with symptomatic oral candidiasis were randomly assigned into two treatment groups: miconazole and miconazole-loaded chitosan nanoparticles. The patients were treated for a duration 28days , and clinical assessments were conducted at baseline, 7, 14, 21 and 28 days. Microbiological analysis was performed to determine the Candida species and assess their susceptibility to the antifungal agents. Clinical parameters, including signs and symptoms of oral candidiasis, were also evaluated. .

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Oral Thrush

Interventions

ChitosanDRUG

chitosan loaded with miconazole nanoparticles gel

Eligibility

Sex: ALLMin age: 30 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. uncontrolled diabetes patients with oral candidiasis and their uncontrolled diabetes were confirmed by doing glycated hemoglobin test and their range is \>7.0%, 2. age ranged from 30-65 years 3. patients were willing to participate in this study Exclusion Criteria: 1. immunocompromised and patients with systemic diseases that can cause muscle weakness as Parkinson's disease, or others that can limit their cognitive functioning such as dementia 2. pregnant 3. nursing women 4. smokers 5. alcoholic patients were also excluded from the study. 6. should not have a history of use of any drugs that can cause hyposalivation or broad spectrum antibiotics, within the last month.

Locations (1)

radwa Elsherif

Giza, Egypt

Outcomes

Primary Outcomes

clinical assessment of erythematous/psuedomembranous oral candidiasis resolution

by Pain analogue scale

Time frame: 28 days

Secondary Outcomes

microbiological count of candida

candidal count by taking swap

Time frame: 28 days

Data from ClinicalTrials.gov

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