Tissue Oxygen Use With Combined Arteriovenous Noninvasive Oximetry

University of Wisconsin, Madison20 enrolled

Overview

The goal of this observational study is to find out if researchers can measure oxygen consumption in the body without having to draw blood from lines in arteries and central veins. Participants will undergo measurements of arterial blood oxygen saturation using both finger and neck pulse oximeters.

TOUCAN-1 is a study to estimate the accuracy and precision of pulse oximetry as a noninvasive tool for oxygen consumption measurement. Researchers will use a pair of commercially-available, noninvasive pulse oximeters to estimate the oxygen saturation of blood in the internal jugular vein, and compare it to the directly measured oxygen saturation in sampled jugular blood. Researchers will then measure the arterial oxygen saturation in a finger, and compare it to the directly measured oxygen saturation in sampled radial arterial blood.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Oxygen Consumption

Interventions

Finger pulse oximetry probeDEVICE

This finger probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.

Transreflectance oximetry probeDEVICE

This neck probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Inpatient at the University of Wisconsin University Hospital * Has an internal jugular venous central line * Has a radial arterial line Exclusion Criteria: * Currently receiving extracorporeal membrane oxygenation (ECMO) * Currently receiving continuous renal replacement therapy (CRRT/CVVH) * All usable lumens of the participant's jugular catheter are in use, and interruption of any medical or therapy through any lumen would, in the view of the primary care team, compromise the participant's care. * Jugular venous catheter is not functional or position is not confirmed by radiography * Arterial cannula is not functional * Known history of sickle cell anemia or other hemoglobinopathy * Therapy with any of the following medications: * Nitroprusside * Hydroxocobalamin * Indocyanine green * Norepinephrine * Vasopressin * Epinephrine * Any other medication or therapy that, in the judgement of the study investigators, may affect the accuracy and precision of the noninvasive oximetry results

Locations (1)

University of Wisconsin

Madison, Wisconsin, United States

Outcomes

Primary Outcomes

Accuracy of digital pulse oximetry

Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry

Time frame: Through study completion, approximately 20 minutes

Accuracy of jugular pulse oximetry

Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry

Time frame: Through study completion, approximately 20 minutes

Data from ClinicalTrials.gov

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