It was previously shown that ICI-colitis can be treated with extracorporeal photophoresis. Therefore this retrospective analysis is launched to study the chnages of immune cells in the peripheral blood and intestinal tract in an ICI colitis patient cohort. The analysis will include the evaluation of intestinal and peripheral blood biomarkers in patients with ICI colitis receiving ECP as a treatment.
It was previously shown that ICI-colitis can be treated with extracorporeal photophoresis. Therefore this retrospective analysis is launched to study the changes of immune cells in the peripheral blood and intestinal tract in an ICI colitis patient cohort. The analysis will include the evaluation of intestinal and peripheral blood biomarkers in patients with ICI colitis receiving ECP as a treatment.
Study Type
OBSERVATIONAL
Enrollment
20
Intestinal tissue analysis
Freiburg University Medical Center
Freiburg im Breisgau, Baden-Wurttemberg, Germany
T cell number and phenotype measurement in the intestinal tract
Analysis of CD3+ T cells by flow cytometry
Time frame: 6 months
T cell number measurement by immunohistochemistry
Analysis of CD3+ T cells by immunohistochemistry
Time frame: 6 months
Analysis of arginase amounts in the intestinal tract using qPCR
Analysis of arginase mRNA expression by realtime PCR (qRT-PCR)
Time frame: 6 months
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