This research study is being conducted to collect information to improve the outcomes of patients who have renal failure and are scheduled to have a sleeve gastrectomy.
We will collect information on changes in physical performance, activity, blood pressure and glucose metabolism, body composition, and the quality of life prior to and three months after sleeve gastrectomy.
Study Type
OBSERVATIONAL
Subjects walk as far as possible for 6 minutes at a self-selected pace, and the total distance walked will be recorded
Subjects will wear an Actigraph on their wrist like a watch for up to 10 days at home to monitor activity.
Subjects will collect glucose values in the fluid under their skin for up to 10 days at home.
Change in 6-minute walk distance (6MWD)
Total distance walked at a self-selected pace reported in meters
Time frame: Baseline, 12 weeks
Change in Short Physical Performance Battery (SPPB) score
Measure of physical performance through balance, strength, and gait measurements. Total score ranges for 0 = worst performance and 12 = best performance.
Time frame: Baseline, 12 weeks
Change in total step count
Total number of steps taken as measured by ActiGraph
Time frame: Baseline, 12 weeks
Change in quality of life
Assessed by the PROMIS 29 questionnaire to assess seven health domains (physical function, anxiety, depression, fatigue, sleep disturbance, ability to participate in social roles and activities, and pain interference) on an individual scoring scale of 1-5 where 1= not all all and 5= very much.
Time frame: Baseline, 12 weeks
Change in glucose metrics
Assessed by continuous glucose metabolism.
Time frame: Baseline, 12 weeks
change in insulin, C peptide and glucose metrics
Assessed by mixed meal testing.
Time frame: Baseline, 12 weeks
Change in blood pressure
Assessed by ambulatory blood pressure monitoring and home blood pressure monitoring
Time frame: Baseline, 12 weeks
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Subjects will monitor their blood pressure at home for 10 consecutive days 3 times a day
24-hour ambulatory blood pressure monitoring
Measure of body fat percentage, skeletal muscle mass, body water, and visceral fat.
Subjects will consume 6 ml/kg body weight of Boost, up to maximum of 360 ml, within 5 min
Subject will complete Quality of Life Questionnaire