Endovascular Treatment for AIS in Chinese Municipal and County Hospitals： A "Real World" Study-ETERNITY Registry

Wen-huo Chen1,196 enrolled

Overview

To investigate the Endovascular Treatment difference between Chinese city and country hospital.

Endovascular Treatment for AIS in Chinese Municipal and County Hospitals： A "Real World" Study-ETERNITY Registry is an academic , independent, pragmatic , prospective , multicenter , observational registry study . Patients with acute ischemic stroke caused by anterior circulation intracranial large vessel occlusion and receiving EVT were included. Patients were divided into primary stroke center (county hospital) and senior stroke center (city hospital) groups. Acute ischemic stroke (AIS) workflow, EVT procedural details and clinical outcome were compared in two groups. The aim of the study was to explore the EVT difference in Chinese city and county hospital.

Study Type

OBSERVATIONAL

Enrollment

1,196

Conditions

Endovascular Treatment

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: (1) age ≥18 years; (2) diagnosis of AIS caused by imaging-confirmed intracranial LVO, including isolated cervical internal carotid artery or tandem occlusion, intracranial internal carotid artery, middle cerebral artery (M1/M2), anterior cerebral artery (A1/A2); (3) initiation of any type of EVT, including mechanical thrombectomy, emergent angioplasty via balloon or/and stent; (4).Onset-to-presentation time with 24 hours; (5).Patients whose onset-to-presentation time surpass 6 hours should had CTP and fulfill with DAWN\[6\] or DEFUSE's\[7\] criteria. Exclusion Criteria: (1) Without follow up outcome; (2) posterior circulation stroke;(3)no evidence of LVO on angiogram.

Locations (1)

Zhangzhou Municipal Hospital

Zhangzhou, Fujian, China

Outcomes

Primary Outcomes

The modified Rankin Scale score at 90 days

The range of the modified Rankin Scale is from 0 to 6. A higher score indicates a worse outcome. 0-No symptoms; 1-No significant disability; 2-Slight disability; 3-Moderate disability; 4-Moderately severe disability; 5-Severe disability; 6-Dead.

Time frame: 90 days

Baseline CT/magnetic resonance and CT angiography/magnetic resonance angiography imaging, digital subtraction angiography

Radiological assessment included ASPECTS ，location of occlusion site, presence of underlying ICAS ，or exist microcatheter "First-Pass Effect".

Time frame: 90 days

Successful reperfusion

Successful reperfusion was defined as eTICI ≥2b

Time frame: 90 days

Data from ClinicalTrials.gov

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