Hemodynamic Effect of Nasal High-flow in Patients Suspected or Followed for a Precapillary Pulmonary Hypertension

ADIR Association20 enrolled

Overview

In this study, the investigators aim to describe the hemodynamic consequences of nasal high-flow measured during right heart catheterization and echocardiography. The research hypothesis is that nasal high-flow would increase cardiac output in patients with pulmonary hypertension. The concomitant echocardiography will allow to describe its sensibility to detect cardiovascular consequences of nasal high-flow.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Pulmonary Hypertension

Interventions

Nasal high-flowDEVICE

Nasal high-flow is a respiratory technique which allows the administration of warmed and humidified air, associated with oxygen if necessary

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- patient addressed for right heart catheterization for pulmonary hypertension suspicion or follow-up. Exclusion Criteria: * necessity of FiO2 \>21% during right heart catheterization * intracardiac shunt * grade 4 tricuspid insufficiency * complete arrhythmia due to atrial fibrillation * Pregnant or breastfeeding women or women of childbearing age without an effective method of contraception * protected adult patient (tutorship or curatorship) * patient deprived of liberty by court or administrative decision * refusal of patient participation or consent * patient for whom the measurement of pulmonary arterial pressures during right heart catheterization is impossible * patient for whom, during the etiological assessment of pulmonary hypertension, the diagnosis of precapillary pulmonary hypertension cannot be confirmed and classified in groups 1, 3 or 4.

Locations (1)

ROUEN university hospital

Rouen, France

RECRUITING

Outcomes

Primary Outcomes

Cardiac output

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

Secondary Outcomes

cardiac output

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

cardiac output

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

Right atrial pressure

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

Right atrial pressure

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

Right atrial pressure

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

systolic pulmonary arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

Central Contacts

Elise ARTAUD-MACARI, MD

CONTACT

+33 2 32 88 59 92 elise.artaud-macari@chu-rouen.fr

Maryline LEFORT, RT

CONTACT

+33 2 32 88 59 92 mlefort@adir-hautenormandie.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

systolic pulmonary arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

systolic pulmonary arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

diastolic pulmonary arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

diastolic pulmonary arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

diastolic pulmonary arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

mean pulmonary arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

mean pulmonary arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

mean pulmonary arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

capillary wedge pressure

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

capillary wedge pressure

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

capillary wedge pressure

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

pulmonary vascular resistance

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

pulmonary vascular resistance

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

pulmonary vascular resistance

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

central venous oxygen saturation

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

central venous oxygen saturation

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

central venous oxygen saturation

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

heart rate

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

heart rate

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

heart rate

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

systolic arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

systolic arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

systolic arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

diastolic arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

diastolic arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

diastolic arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

mean arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

mean arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

mean arterial pressure

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

systolic ejection volume

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

systolic ejection volume

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

systolic ejection volume

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

respiratory rate

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

respiratory rate

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

respiratory rate

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

pulse oxygen saturation

Changes measured during cardiac catheterization under nasal high-flow 50L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

pulse oxygen saturation

Changes measured during cardiac catheterization under nasal high-flow 30L/Min FiO2 21% as compared to room air

Time frame: During the intervention, at isotime

pulse oxygen saturation

Changes measured during cardiac catheterization under nasal high-flow 30 and 50 L/min

Time frame: During the intervention, at isotime

Consequences of nasal high-flow 50 and 30 L/min FiO2 21% on echocardiographic parameters.

Cardiac output, inferior vena cava diameter and collapsibiliy, systolic pulmoanry arterial pressure, tricuspid regurgitation velocity,tricuspid annular plane systolic excursion, right ventricule strain, tricuspid S wave, right on left ventricular telediastolic surface ratio, left ventricular ejection fraction, mitral doppler, mitral S wave, respiratory variability of E mitral wave

Time frame: During the intervention, at isotime

systolic pulmonary arterial pressure measured by catheterization and echocardiography.

Concordance and correlation of hemodynamic parameters measured by catheterization and echocardiography.

Time frame: During the intervention, at isotime

capillary wedge pressure measured by catheterization and echocardiography.

Concordance and correlation of hemodynamic parameters measured by catheterization and echocardiography.

Time frame: During the intervention, at isotime

right atrial pressure measured by catheterization and echocardiography.

Concordance and correlation of hemodynamic parameters measured by catheterization and echocardiography.

Time frame: During the intervention, at isotime

cardiac output measured by catheterization and echocardiography.

Concordance and correlation of hemodynamic parameters measured by catheterization and echocardiography.

Time frame: During the intervention, at isotime