The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.
Since May 2008, PPS3 is being following the CVD morbidity of 10157 healthy volunteers aged 50-75 years at baseline. In PPS3-2, we plan to re-invite survivors and volunteers of PPS3 to undergo a second physical examination. In particular, they will undergo a second high-precision carotid echotracking to measure vascular aging parameters and baroreflex sensitivity, permitting to study their respective dynamics. They will also underwent for the first time ultra fast echo of the radial artery to measure vascular aging parameters of the medium-sized arteries. According to fundings, blood samples will be taken and stored at -80°C in the whole population or in a subsample.
Study Type
OBSERVATIONAL
Enrollment
7,500
evaluation of vascular aging parameters and baroreflex sensitivity
Centre d'Investigation Précliniques
Paris, France
RECRUITINGcarotid diameter
high precision carotid echo tracking diameter in mm
Time frame: by 2027
intima media thickness
high precision echo tracking intima media thickness of the common carotid artery in mm
Time frame: by 2027
carotid plaques
high precision carotid echo tracking carotid plaques
Time frame: by 2027
wall cross sectional area
high precision carotid echo tracking carotid wall cross sectional area, mm2
Time frame: by 2027
distensibility coefficient
high precision carotid echo tracking distensibility coefficient in 10-3/kPa
Time frame: by 2027
elastic modulus
high precision carotid echo tracking Young's elastic modulus, 10-3\*kPa
Time frame: by 2027
pulse wave velocity
high precision carotid echotracking pulse wave velocity, m/s
Time frame: by 2027
carotid wall stress
high precision carotid echotracking circumferential wall stress in kPa
Time frame: by 2027
stiffness
high precision carotid echotracking Beta stiffness index
Time frame: by 2027
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
pulse pressure
high precision carotid echotracking pulse pressure in mmHg
Time frame: by 2027
brachial artery diameter
ultra high frequency ultrasound radial artery diameter in mm
Time frame: by 2027
thickness of the intima media of the radial artery
ultra high frequency ultrasound radial artery intima media thickness in mm
Time frame: by 2027
arterial plaques
ultra high frequency ultrasound radial artery plaques
Time frame: by 2027
wall cross sectional area of the radial artery
ultra high frequency ultrasound radial artery wall cross sectional area, mm2
Time frame: by 2027
distensibility of the radial artery
ultra high frequency ultrasound radial artery distensibility coefficient in 10-3/kPa
Time frame: by 2027
elastic modulus of the radial artery
ultra high frequency ultrasound radial artery Young's elastic modulus, 10-3\*kPa
Time frame: by 2027
pulse wave velocity of the radial artery
ultra high frequency ultrasound radial artery Pulse wave velocity, m/s
Time frame: by 2027
stiffness index of the radial artery
ultra high frequency ultrasound radial artery Beta stiffness index
Time frame: by 2027
wall stress of the radial artery
ultra high frequency ultrasound radial artery Circumferential wall stress, kPa
Time frame: by 2027
pulse pressure of the radial artery
ultra high frequency ultrasound radial artery Pulse Pressure, mmHg
Time frame: by 2027