The purpose of this study is to assess the effects of Cetyl Tranexamate Mesylate on acne-related hyperpigmentation through a specific delivery form known as TeraCeutic TXVector.
Hyperpigmentation is characterized as an increase in pigment on the skin and is a common skin condition in individuals with skin types III to VI on the Fitzpatrick skin classification scale. Hyperpigmentation can be localized to an area in the form of post-inflammatory hyperpigmentation or diffused in the form of melasma. One of the treatments that are used to treat hyperpigmentation is tranexamic acid (TXA) which is a third-generation bioactive and is formally known to work as a plasmin inhibitor. Since TXA is hydrophilic in nature and has a strong hydrogen-bonding capacity, it has an insufficient skin permeability. Similar to TXA esters, Cetyl Tranexamate Mesylate (CTM) is hypothesized to have greater permeability and this study will evaluate the effects of CTM on the appearance of post-inflammatory hyperpigmentation.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
22
Topical product will be applied onto clean skin morning and night.
Integrative Skin and Research
Sacramento, California, United States
Facial skin pigment intensity of 3 pre-identified lesions
Change in the appearance of pigment intensity (melanin measurement) of 3 pre-identified hyperpigmented lesions
Time frame: 2 weeks
Facial skin pigment intensity of 3 pre-identified lesions
Change in the appearance of pigment intensity (melanin measurement) of 3 pre-identified hyperpigmented lesions
Time frame: 1 week
Self-perception of skin pigmentation
Survey-based self-assessment of facial skin pigmentation
Time frame: 1 week
Self-perception of skin pigmentation
Survey-based self-assessment of facial skin pigmentation
Time frame: 2 week
Self-perception of skin redness
Survey-based self-assessment of aspects of skin redness
Time frame: 1 week
Self-perception of skin redness
Survey-based self-assessment of aspects of skin redness
Time frame: 2 week
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