The Choice of Treatment Methods and Efficacy of LABC

Inclusion Criteria: 1. 18-70 year old female 2. Patients with locally advanced breast cancer (stage IIIb - IIIc) first diagnosed; 3. Clinical diagnosis of breast cancer, or puncture pathology suggests breast cancer; 4. After evaluation by experienced clinical physicians, the patient's tumor has the possibility of surgical resection. Specific evaluation indicators include ultrasound assessment of the tumor not surrounding the axillary vein; 5. Accept treatment plans including surgery, radiotherapy, and chemotherapy; 6. Volunteer to participate in clinical research and sign an informed consent form; 7. Willing to undergo follow-up and complete quality of life (EQ-5D series scale and FACT-B scale) and postoperative psychological status (Anxiety/Depression Self Rating Scale) assessments; Exclusion Criteria: 1. Patients under 18 years old or over 70 years old; 2. Those who have received breast cancer related surgery, radiotherapy or chemotherapy; 3. Those who are not expected to receive surgery, radiotherapy or chemotherapy related to breast cancer 4. History of other malignant tumors; 5. Pregnant or lactating women; 6. Accompanying active infection and fever; 7. Other serious diseases that may significantly affect clinical trial compliance, such as severe cardiopulmonary dysfunction, liver and kidney dysfunction, poorly controlled diabetes and mental illness.