Normative Brain Volume Profiles From Multicenter Fetal MRI

Assistance Publique Hopitaux De Marseille1,423 enrolled

Overview

Fetal brain MRI is an essential diagnostic tool to inform parents about the prognosis of abnormalities detected on routine ultrasound. Recent work has shown that brain MRI measurements at the antenatal stage are predictive of the child's postnatal development. However, this work remains limited to basic research, in part because of the lack of normative curves of brain tissue volume evolution from fetal MRI acquired in clinical routine. This project aims to fill this gap. For this purpose, the project will exploit fetal MRI scans acquired in 4 French hospitals (Marseille, Nice, Montpellier and Paris): MRI scans without abnormalities will be centralized for analysis, and families who have undergone these scans will be contacted to evaluate the development of their children after birth. Normative curves will be established by applying a set of treatments developed by the laboratory in Marseille collaborating in the project. Ultimately, these curves will help to clarify the diagnosis of fetuses by providing a quantitative characterization of the normality of brain measurements.

Study Type

OBSERVATIONAL

Enrollment

1,423

Conditions

Cortical Development Malformation Multiparametric Magnetic Resonnance Imaging Brain Cortical Thickness Prenatal Diagnosis Fetal Development

Eligibility

Sex: ALLMin age: 20 WeeksMax age: 37 WeeksHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Child who has had, more than 3 years ago, a cerebral MRI during the fetal period in one of the 4 partner centers Exclusion Criteria: * Child suffering from a commissural malformation (anomaly of the corpus callosum) * Child with a genetic syndrome and/or chromosomal abnormality and/or deleterious mutation * Child with syndromic extra-cerebral malformations (including cardiac malformations) * Child with intrauterine growth restriction reported in the obstetrical record * Child with maternal-fetal infection (TORCH, parvovirus or other) confirmed by amniotic fluid test or neonatal urine test * Multiple pregnancy * Mother with diabetes treated during pregnancy (including gestational diabetes, if treated) * Mother with antiepileptic medication during pregnancy * Alcohol or drug use * Presence of a sustentorial arachnoid cyst * Presence of an arachnoid cyst with mass effect * Objection from parental authority holders to participate in the study

Outcomes

Primary Outcomes

Determine normative brain volume curves

Curves calculated from fetal brain MRIs in fetuses between 20 and 37 weeks of amenorrhea with normal postnatal neurological development

Time frame: Through study completion, an average of 3 year

Secondary Outcomes

Statistically compare the normative curves obtained with standard articles in the literature.

Comparaison of Size effect, confidence intervals obtained with those reported in the reference articles

Time frame: Through study completion, an average of 3 year

Sensitivity study: Possible influence of the scanner type on the estimated normative curves.

MRI scanner model

Time frame: Through study completion, an average of 3 year

Normative Brain Volume Profiles From Multicenter Fetal MRI

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts