The endocannabinoid system (ECS) is a complex endogenous signaling system made up of transmembrane cannabinoid receptors (CB1 and CB2 receptors), their endogenous lipid-derived ligands (the endocannabinoids - eCBs), and enzymes for ligand biosynthesis and degradation. Interestingly, exercise increase plasma AEA, one of the most famous endocannabinoid. This increase could be involved in exercise-induced neurogenesis and other beneficial exercise adaptations. Chronic cannabis use is associated with alteration of ECS activity. The aim of the study is to compare ECS response to exercise between chronic cannabis users and non-users.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
60
Over 2 weeks, participants have to do a maximal progressive exercise and a 30 min constant exercise at 50% of maximal aerobic power
CHU Lille
Lille, France
RECRUITINGPlasma endocannabinoids levels (pmol/ml)
Time frame: 2 weeks
regulating hormone of endocannabinoids (plasma levels of cortisol, ng/ml)
Time frame: 2 weeks
Blood marker of neurogenesis and neuroplasticity (plasma levels and BDNF, pg/ml)
Time frame: 2 weeks
change in cerebral muscular, oxygenation (HHB), (HbO2), (Hbtot) (arbitrary unit)
Time frame: 2 weeks
Cognitive function (selective attention, stroop test)
The stroop test can be used to measure a person's selective attention capacity
Time frame: 2 weeks
Oxygen consumption (VO2) (ml/min/kg)
Time frame: 2 weeks
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