"KB-120" small molecular nutrient is a structural multi-molecular natural nutrient with different components. It is produced from strains and natural plant culture-medium that can be used in food and is designed according to different efficacy of different products by multi-stage solid-liquid complex fermentation technology. The functional directions of the product series involved are: immune function damage repair, intestinal villi damage repair, sperm development machinery damage repair, ovarian function damage repair, liver function damage repair, sleep disorder function damage repair, etc.Previous studies have shown that "KB-120" has good clinical effects on improving the number and function of male germ cells.Luanbao "KB-120" is a compound plant health drink specially for women. This study intends to give "KB-120" small molecule nutrients as nutritional supplement intervention in female patients with ovarian dysfunction, and observe its influence on endocrine function, ovarian reserve function and fertility in patients with ovarian dysfunction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
80
The experimental group was given oral "KB-120" small molecular nutrients, once a day, once a bag (30ml), and vitamin E100mg orally twice a day for a total of 3 menstrual cycles
Vitamin E100mg is taken orally twice a day for a total of 3 menstrual cycles
Concentration of serum FSH 1
Blood samples were collected on the 3rd day of the 2nd menstruation
Time frame: on the 3rd day of the 2nd menstruation（each cycle is 23-30 days）
Concentration of serum FSH 2
Blood samples were collected on the 3rd day of the 4th menstruation
Time frame: on the 3rd day of the 4th menstruation（each cycle is 23-30 days）
Concentration of serum AMH 1
Blood samples were collected on the 3rd day of the 2nd menstruation
Time frame: on the 3rd day of the 2nd menstruation（each cycle is 23-30 days）
Concentration of serum AMH 2
Blood samples were collected on the 3rd day of the 4th menstruation
Time frame: on the 3rd day of the 4th menstruation（each cycle is 23-30 days）
The number of days of the menstrual cycle 1
The number of days of the menstrual cycle 1
Time frame: At the end of Cycle 1 （each cycle is 23-30 days）
The number of days of the menstrual cycle 3
The number of days of the menstrual cycle 3
Time frame: At the end of Cycle 3（each cycle is 23-30 days）
The diameter of dominant follicle and the number of days required for ovulation 1
The follicle development of patients was monitored by ultrasound during the 1st menstrual cycle, and the monitoring interval was determined according to the clinical experience of clinicians and the development of patients' follicles
Time frame: At the end of Cycle 1 （each cycle is 23-30 days）
The diameter of dominant follicle and the number of days required for ovulation 2
The follicle development of patients was monitored by ultrasound during the 3rd menstrual cycle, and the monitoring interval was determined according to the clinical experience of clinicians and the development of patients' follicles
Time frame: At the end of Cycle 3 （each cycle is 23-30 days）
pregnancy rate for women trying to get pregnant 1
pregnancy rate for women trying to get pregnant
Time frame: At the end of Cycle 1 （each cycle is 23-30 days）
pregnancy rate for women trying to get pregnant 2
pregnancy rate for women trying to get pregnant
Time frame: At the end of Cycle 3 （each cycle is 23-30 days）
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