Correlation Between Perioperative EEG Features and Delirium After General Anesthesia

N/AUnknownNCT06082024

Fuzhou Hua40 enrolled

Overview

The goal of this observational study is to compare the perioperative EEG characteristics and the incidence of short-term cognitive dysfunction in patients with postoperative delirium and non-postoperative delirium after elderly (\> 65 years old) patients undergoing major gastrointestinal surgery under general anesthesia. The main question it aims to answer are: • The correlation between postoperative cognitive dysfunction and postoperative EEG features was evaluated.• To analyze the correlation between EEG characteristics and clinical risk factors of delirium after major abdominal gastrointestinal surgery under general anesthesia in elderly patients.Participants will collect EEG before and after operation and collect the incidence of postoperative cognitive function to explore the mechanism of postoperative delirium and predict postoperative cognitive dysfunction.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Perioperative Period Anesthetic Postoperative Cognitive Dysfunction Postoperative Delirium

Eligibility

Sex: ALLMin age: 65 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Education level in primary school or above; 2. Age ≥65 years old, gender is not limited; 3. Good communication ability, language expression ability, mental state and consciousness state; 4. Preoperative simple mental state scale score ≥27 points; 5. no history of craniocerebral diseases; 6. For patients who plan to choose abdominal surgery under general anesthesia, the operation time is expected to be about 2h-4h; 7. ASA anesthesia grade I \~ III; 8. No general anesthesia contraindications; 9. Sign informed consent voluntarily; Exclusion Criteria: 1. Relative contraindications of general anesthesia: patients with serious heart and lung function diseases, drug allergy history, etc. 2. Patients with a history of mental illness or long-term psychiatric drugs (dementia, schizophrenia), chronic analgesic drug use history, alcoholism history and cognitive dysfunction; 3. any cerebrovascular accident occurred within 3 months, such as stroke, transient ischemic attack (TIA), etc. 4. Diabetic patients with severe diabetic complications (diabetic ketoacidosis, hyperosmolar coma, various infections, macrovascular disease, diabetic nephropathy); 5. Chronic hypoxia and carbon dioxide storage, such as chronic obstructive emphysema; 6. a long history of alcohol abuse; 7. Unable to cooperate to complete the test, the patient or family rejected the participant.

Outcomes

Primary Outcomes

wave time-frequency analysis

The characteristics of four kinds of brain wave α, β ,δ and θ were analyzed by professional EEG analysis software

Time frame: one day before surgery, 7-10 days after surgery

P300 latency and peak changes

The feature analysis of event-related potentials was carried out through professional EEG analysis software

Time frame: one day before surgery, 7-10 days after surgery

EEG event-related potential accuracy and response time

The accuracy of task EEG was analyzed statistically by using professional EEG analysis software

Time frame: one day before surgery, 7-10 days after surgery

Incidence of postoperative short-term cognitive dysfunction

A telephone return visit was conducted on patients using the Revised Cognitive Function Telephone Questionnaire (TICS-M) at 1, 3, and 6 months after discharge.The total score was less than 28 points, which was considered as cognitive impairment.

Time frame: postoperative 1,3,6 months

Secondary Outcomes

Systolic pressure

"just entering the operating room", "immediately after intubation", "every 5 minutes after intubation until the patient leaves the operating room".

Time frame: perioperative period

Diastolic pressure

"just entering the operating room", "immediately after intubation", "every 5 minutes after intubation until the patient leaves the operating room".

Time frame: perioperative period

Mean pressure

"just entering the operating room", "immediately after intubation", "every 5 minutes after intubation until the patient leaves the operating room".

Time frame: perioperative period

Heart rate

"just entering the operating room", "immediately after intubation", "every 5 minutes after intubation until the patient leaves the operating room".

Time frame: perioperative period

Maximum postoperative C-reactive protein (CRP)

Only the highest CRP values detected in the normal course of gastrointestinal surgery are collected, and no additional blood sampling or interventions are performed

Time frame: Up to 1 month after surgery

Minimum postoperative albumin

Only the lowest albumin values detected in the normal course of gastrointestinal surgery are collected, and no additional blood sampling or interventions are performed

Time frame: Up to 1 month after surgery

Postoperative pain

The degree of postoperative pain was assessed using the Numerical Rating Scale (NRS). The pain level increased sequentially from 0-10

Time frame: 1, 3, and 7 days after surgery

Complication

All the perioperative complications are recorded

Time frame: During the perioperative period, up to 1 month after surgery

Length of hospitalization

The total number of days the patient spent at the hospital for the current consultation

Time frame: After the patient is discharged from the hospital, average 1 month

Correlation Between Perioperative EEG Features and Delirium After General Anesthesia

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts