The NetherLands Registry of Invasive Coronary Vasomotor Function Testing (NL-CFT)

N/AEnrolling By InvitationNCT06083155

Radboud University Medical Center2,000 enrolled

Overview

The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational. Patients receive yearly online questionnaires on their anginal complaints for 5 years after their CFT.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Coronary Vasospasm Coronary Microvascular Dysfunction Non-Obstructive Coronary Atherosclerosis

Interventions

Coronary Function TestDIAGNOSTIC_TEST

All participants are referred for a clinically indicated coronary function test

Patient questionnairesOTHER

All participants that consent will receive yearly followup questionnaires for 5 years after their initial consent

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Referred for clinically indicated CFT Exclusion Criteria: * Not willing to provide informed consent

Locations (15)

RadboudUMC

Nijmegen, Gelderland, Netherlands

Amsterdam UMC

Amsterdam, Netherlands

Onze Lieve Vrouwe Gasthuis (OLVG)

Amsterdam, Netherlands

Outcomes

Primary Outcomes

Prevalence of coronary vasomotor dysfunction

Can be handled as dichotomous outcome with normal vs abnormal coronary function test (CFT) results. Alternatively, can also be handled as categorical outcome with the following categories. 1. Normal CFT results 2. Vasospastic endotype (epicardial or microvascular); tested by acetylcholine provocation 3. Microvascular dysfunction endotype (decreased coronary flow reserve or increased index of microvascular resistance); tested by bolus thermodilution, optionallly with additional continuous thermodilution method 4. Mixed endotype

Time frame: Baseline

Secondary Outcomes

Angina burden

Measured by Seattle Angina Questionnaire summary score, 0-100 with higher scores indicating better (functional) status.

Time frame: Baseline and every year up to 5 years after baseline

Experienced quality of life

Measured by Short Form 36, 0-100 with higher scores indicating better quality of life

Time frame: Baseline and every year up to 5 years after baseline

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.