The present study is a randomized clinical trial (RCT). Patients responding to the inclusion criteria will be included. The following peri-implant indexes will be collected: Bleeding On Probing, Gingival Bleeding Index, Marginal Mucosal Conditions (swelling and erythema), Suppuration, Mucosal margin migration, PPD Probing Pocket Depth, Plaque Index, Bleeding Score, radiographic bone loss. After the peri-implant evaluation, patients will undergo supragingival and subgingival professional oral hygiene of both arches performed with ultrasonic instrumentation with PEEK inserts, manual instrumentation with teflon curettes and air polishing with glycine powder. After that, the sample will be randomly divided into 2 groups based on thein-office assigned treatment: * Chlosite® gel application in the peri-implant sulcus * Hybenix® gel application for 30 s followed by rinsing of the peri-implant sulcus. The study will last 9 months. Patients will be visited at: T0, after 1 month from T0 (T1), after 3 months (T2), after 6 months (T3) and after 9 months (T4). In each time frame, indexes collection and nonsurgical debridement will be performed.
The present study is designed as a randomized clinical trial (RCT) to evaluate the clinical efficacy of two adjuvant gels in the treatment of perimplantitis. Patients responding to the inclusion criteria will be included in the study. The following peri-implant indexes will be collected: * BOP (Bleeding On Probing) * GBI (Gingival Bleeding Index) * Marginal Mucosal Conditions (swelling and erythema) * Suppuration * Mucosal margin migration * PPD (Probing Pocket Depth) * PI (Plaque Index) * BS (Bleeding Score) * Radiographic bone loss After the peri-implant evaluation, patients will undergo supragingival and subgingival professional oral hygiene of both arches performed with ultrasonic instrumentation with PEEK inserts, manual instrumentation with teflon curettes and air polishing with glycine powder. After that, the sample will be randomly divided into 2 groups based on thein-office assigned treatment: * Chlosite® gel application in the peri-implant sulcus * Hybenix® gel application for 30 s followed by rinsing of the peri-implant sulcus. The study will last 9 months. Patients will be visited at: T0, after 1 month from T0 (T1), after 3 months (T2), after 6 months (T3) and after 9 months (T4). In each time frame, indexes collection and nonsurgical debridement will be performed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
Clinical application of Hybenix gel after professional dental hygiene of peri-implant mucositis sites.
Clinical application of Chlosite gel after professional dental hygiene of peri-implant mucositis sites.
Unit of Dental Hygiene - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia
Pavia, Lombardy, Italy
Change in BOP - Bleeding On Probing
Dichotomous scoring (yes/no)
Time frame: Baseline, 1, 3, 6 and 9 months.
Change in GBI - Gingival Bleeding Index (percentage)
Site-specific assessment of the presence or absence of gum bleeding after the insertion of the periodontal probe for the detection of PPD, detected on 6 sites. The number of bleeding sites is divided per the total number of probed sites; the ratio is multiplied X 100.
Time frame: Baseline, 1, 3, 6 and 9 months.
Change in marginal mucosa condition
Scoring criteria: 0: normal mucosa 1. minimal inflammation with color change and minor edema 2. moderate inflammation with redness, edema and glazing 3. severe inflammation with redness, edema, ulceration and spontaneous bleeding without probing
Time frame: Baseline, 1, 3, 6 and 9 months.
Change in suppuration
Dichotomous scoring (yes/no)
Time frame: Baseline, 1, 3, 6 and 9 months.
Marginal mucosal migration
Dichotomous scoring (yes/no)
Time frame: Baseline, 1, 3, 6 and 9 months.
Probing Depth
Evaluation (in mm) of the depth of the mucosal sulcus, through a millimeter periodontal probe; it is detected from the mucosal margin to the bottom of the peri-implant sulcus, evaluated at 6 sites.
Time frame: Baseline, 1, 3, 6 and 9 months.
Change in BS - Bleeding Score
Scoring criteria: 0: no bleeding 1. isolated visible spots 2. blood forms a confluent red line on mucosal margin 3. heavy or profuse bleeding
Time frame: Baseline, 1, 3, 6 and 9 months.
Change in PI - Plaque Index (percentage)
Evaluation of the presence of plaque on the 4 surfaces of teeth on the total amount of dental surfaces.
Time frame: Baseline, 1, 3, 6 and 9 months.
Change in Radiographic bone loss (percentage)
Quantitative evaluation of the bone loss evaluated on intraoral x-rays.
Time frame: Baseline, 1, 3, 6 and 9 months.
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