Unravelling Tumour Biology In Ovarian Cancer With Precision Imaging

Institut du Cancer de Montpellier - Val d'Aurelle120 enrolled

Overview

The objective of this study is to explore the integration of in vivo and ex vivo of MRI with histology and molecular assessments to advance non-invasive characterization of tumor heterogeneity in high-grade serous ovarian cance

After being informed about the study and potential risks, all patient giving wirtting informed consent. During surgery, tissue and blood samples will be conserved for the study. In this study will be compared images obtained in vivo before surgical management, ex vivo images obtained on excised tissues during surgery, histological data obtained during surgery.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

120

Conditions

High Grade Serous Ovarian Cancer

Interventions

Blood sample and tissue sampleBIOLOGICAL

During the surgery : * Tissus sample : primary tumor and metastasis * blood sample : 3 EDTA tubes * ex vivo MRI data

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient aged \>18 * Pathologically proven HGSOC at an advanced stage (FIGO IIIB or IIIC) which can benefit from surgery with or without prior neoadjuvant treatment * Willingness and ability to comply with planned visits, treatment plan, laboratory tests and other study procedures, * Patient who has given informed, written and express consent, * Patient affiliated with a French health insurance scheme. Exclusion Criteria: * Early-stage disease (FIGO \<IIIB) or presence of extraperitoneal metastases, * Patient who will not have surgery * Patient whose regular follow-up is impossible for psychological, family, social or geographical reasons, * Patient under guardianship, curatorship or safeguarding of justice, * Pregnant and/or nursing patient, * Patient with a history of other cancers within 5 years/10 years prior to inclusion

Locations (1)

NOUGARET Stephanie

Montpellier, France

RECRUITING

Outcomes

Primary Outcomes

the integration of in vivo and ex vivo of MRI with histology and molecular assessments to advance non-invasive characterization of tumor heterogeneity in high-grade serous ovarian cancer.

The diagnostic performance of the radiomic and multiomic algorithm for the characterization of heterogeneity in the CSOHG.