Study of RPT193 in Healthy Adult Male Subjects

Inclusion Criteria: * Continuous non-smoker who has not used nicotine- and tobacco-containing products for at least 3 months prior to dosing * Body mass index (BMI) ≥ 18.0 and ≤ 32.0 kg/m2 at the screening Exclusion Criteria: * Is mentally or legally incapacitated or has significant emotional problems at the time of the screening visit * History or presence of clinically significant medical or psychiatric condition or disease * History or presence of alcohol or drug abuse within the past 2 years prior to dosing * History or presence of: * Gastrointestinal ulcers, or history of other significant GI diseases * Malignancy within the last 5 years, with the exception of successfully treated basal cell carcinoma. * Clinically significant history of angina, myocardial infarction, syncope, clinically significant cardiac arrhythmias, left ventricular hypertrophy, cardiomyopathy, or any other cardiovascular abnormality * Ongoing or recent (within 30 days prior to RPT193 administration) bacterial, fungal, or viral infection requiring therapy * Known family history of sudden death. * Positive for human immunodeficiency virus, hepatitis B, hepatitis C * Unwilling to abstain from alcohol, xanthane-containing beverages or food or foods containing grapefruit/Seville orange prior to admission * Received radiolabeled substances or exposed to radiation sources over past 12 months