Immune response to influenza vaccine in kidney transplant patients
Seasonal influenza vaccination is recommended for kidney transplant patients, as influenza is responsible for significant morbidity and mortality in this immunocompromised population. Nevertheless, injection of influenza vaccine induces a protective immune response in only 20% to 40% of patients. Today, there are no recommendations regarding the injection time of influenza vaccine in the general population or in immunocompromised patients. In this context, recent studies conducted in healthy subjects have shown that the time of vaccination can have an impact on vaccine efficacy. This is the case for BCG, influenza, COVID-19. On this basis, we formulate the main hypothesis that the administration of influenza vaccine to kidney transplant patients would be more effective when carried out in the morning than in the evening.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
38
Injection of the vaccine in renal transplant patients.
CHU Nice - Hôpital Pasteur 2
Nice, Alpes-Maritimes, France
Comparison of antibody titer (seroconversion) 4 weeks after inactivated influenza vaccine injection in each arm.
Seroconversion will be defined as an increase in antibody titer of at least 4-fold (≥4) over pre-vaccination titer AND an antibody titer ≥ 1:40 (seroprotection) four weeks post-vaccination, for at least one of the three vaccine antigens.
Time frame: 7 months
Number of seasonal influenza virus infections in each arm.
Comparing the number of seasonal influenza virus infections in kidney transplant patients between a group of patients vaccinated in the morning and a group vaccinated in the evening. The occurrence of influenza, as confirmed by a PCR test, will be noted in the follow-up consultation.
Time frame: 8 months
Comparison the evolution of antibody titres reacting in each arm.
In kidney transplant patients, compare the evolution of antibody titres reacting with vaccine antigens 4 weeks after influenza vaccination between a group of patients vaccinated in the morning and a group of patients vaccinated in the evening. The titer of antibodies reacting with vaccine antigens is measured by ELISA ;
Time frame: 7 months
Evolution of the number of memory B cells in each arm.
To compare in kidney transplant patients the evolution of the number of memory B cells reacting with vaccine antigens 4 weeks after influenza vaccination between a group of patients vaccinated in the morning and a group of patients vaccinated in the evening. The number of memory B cells reacting with vaccine antigens will be measured by ELISPOT ;
Time frame: 7 months
Evolution of the number of CD4+ T cells in each arm.
Comparing the evolution of CD4+ T cells reacting with vaccine antigens in kidney transplant patients 4 weeks after influenza vaccination between a group of patients vaccinated in the morning and a group of patients vaccinated in the evening. The number of CD4+ T cells reacting with vaccine antigens will be measured by in vitro proliferation assay;
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Time frame: 7 months
Evolution of the number of CD8+ T cells in each arm.
Comparing the evolution of CD8+ T cells reacting with vaccine antigens in kidney transplant patients 4 weeks after influenza vaccination between a group of patients vaccinated in the morning and a group of patients vaccinated in the evening. The number of CD8+ T cells reacting with vaccine antigens will be measured by in vitro proliferation assay;
Time frame: 7 months