Liquid Biopsy for the Diagnosis of Intestinal-type Adenocarcinoma of the Ethmoid (BLADE)

Inclusion Criteria: * Case group: diagnosis of adenocarcinoma of the ethmoid on biopsy or imaging recurence; age\>/= 18 years; patient consent ; * Age and gender-matched control group: consulting patient in otolaryngology head and neck surgery department without adenocarcinoma of the ethmoid; no personal history of cancer; no familial history of colorectal adenocarcinoma; * Exposition control group: Professional exposition to wood dust, leaver or nickel for at least 12 months; consulting patient in otolaryngology head and neck surgery department without adenocarcinoma of the ethmoid; no personal history of cancer; no familial history of colorectal adenocarcinoma; Exclusion Criteria: * patient presenting with another malignant tumor * deprivation of liberty * patient under guardianship * Other cancer diagnosed or under treatment * Recurrent patient previously included in the study * Refusal to accept the monitoring described and/or to provide the information required for the study * No affiliation or non-beneficiary of a Social Security system; * Pregnant or breast-feeding women in accordance with article L1121-5 of the Public Health Code (CSP)