Periodontitis is an inflammatory disease that causes destruction of periodontal tissues. IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. The aim of this study was to evaluate the effect of IL-20 on periodontal destruction. In the study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group) and 30 of whom were systemically healthy and had periodontitis (periodontitis group). GCF and serum samples were collected from the participants for biochemical analysis. ELISA method was used to determine IL-20, TNF-α, IL1β/IL-10, RANKL/OPG and MMP8 levels
Study Type
OBSERVATIONAL
Enrollment
60
GCF and serum samples were collected from the participants for biochemical analysis.
Recep Tayyip Erdogan University
Rize, Turkey (Türkiye)
concentration of biochemical findings in gingival crevicular fluid (GCF)
IL-20, RANKL, OPG and RANKL/OPG values eveluated in GCF
Time frame: june 2022-june 2023
concentration of biochemical findings in serum
IL-20, RANKL, OPG, RANKL/OPG, MMP-8, TNF-α, IL-1β, IL-10 and IL-1β/IL-10
Time frame: 1 year
value of periodontal clinical parameters
plaque index (PI) (Silness \& Löe), gingival index (GI) (Silness \& Löe) and bleeding on probing index (BOP) of all natural teeth of the patients
Time frame: 1 year
value of periodontal clinical parameters were measured in mm
probing pocket depth (PPD), clinical attachment loss (CAL) of all natural teeth of the patients
Time frame: 1 year
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