Gene Expression Profiling in a Validation Cohort of Locally Advanced and Recurrent/Metastatic Salivary Gland Cancers

N/ANot Yet RecruitingNCT06091878

Royal Marsden NHS Foundation Trust250 enrolled

Overview

The INDAGA-UK trial is a retrospective, multi-centre observational study in participants with locally advanced and recurrent salivary gland to investigate t its molecular profiling, and to explore new prognostic and druggable markers. We will analyse samples and data from patients diagnosed with salivary gland cancer from 2013 - 2023. Subject and sample identification will occur over a 12-month period. Samples and data will be analysed over the next 12 months prior to study end.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Salivary Gland Cancer

Interventions

ObservationOTHER

Observational study, no intervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Aged over 18 2. Histological diagnosis of salivary gland cancer (SGCs) 3. Availability of archival tissue (acceptable after 2013 up to present) 4. Ability to give informed consent (if applicable)\* for retrieving histological specimen and preform molecular analysis \*De-identified archival tissue from deceased patients will be collected as part of the study once REC approval is in place, if the patient was alive when the samples were taken and they are not part of the NHS opt out scheme. Exclusion Criteria: 1. Different H\&N cancer of other histology 2. Thyroid cancers

Outcomes

Primary Outcomes

• Description of the molecular and genomic profile of locally advanced and recurrent-metastatic SGCs.

Time frame: Time Frame: Through study completion, expected duration of 10 years

Central Contacts

Pablo Jimenez

CONTACT

02073528171 pablo.jimenez@rmh.nhs.uk

Sarah Burton

CONTACT

02073528171 sarah.burton@rmh.nhs.uk

Data from ClinicalTrials.gov

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