Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients

Delta NT-pro BNP

Delta NT-proBNP from admission to discharge and 90-days follow up

Time frame: From admission to discharge and 90 days after hospitalisation

Successful decongestion

Number of participants with successful decongestion (defined as a clinical congestion score of 2 or less and NYHA I-II)

Time frame: Day 3 after inclusion

Change in clinical congestion score

Change in clinical congestion score from admission to discharge

Time frame: From date of randomization until date of hospital discharge (regarding initial hospitalisation at time of randomisation, assessed up to 90 days),

Quality of life (Kansas City Cardiomyopathy Questionnaire)

Quality of life assessed using the Kansas City Cardiomyopathy Questionnaire

Time frame: 90 days after inclusion

Adverse (safety) events

All-cause readmissions at 90-days, all-cause and cardiovascular mortality at 90-days, (symptomatic) hypotension, hypokalemia, urinary tract infection, phlebitis, atrial fibrillation, fall/trauma and decompensated HF

Time frame: 90 days after inclusion

All-cause mortality and heart failure readmissions

All-cause mortality and heart failure readmissions at 14 days follow up

Time frame: 14 days after inclusion

All-cause mortality and heart failure readmissions

All-cause mortality and heart failure readmissions at 6 months follow up

Time frame: 6 months after inclusion

Chronic dialysis

Occurence of the need for chronic dialysis at 90-days follow up

Time frame: 90 days after inclusion

Days alive outside the hospital

Days alive outside the hospital at 90-days follow up

Time frame: 90 days after inclusion

Time to first heart failure hospitalization and number of heart failure hospitalizations

Time to first heart failure hospitalization and number of heart failure hospitalizations

Time frame: 90 days after inclusion

Number of outpatient visits

Number of outpatient visits in the first 90 days

Time frame: 90 days after inclusion

Number of worsening heart failure events

Number of worsening heart failure events at 90 days: i) a \>2 times increase in oral loop diuretic dose, ii) the need for iv administration of loop diuretics, iii) an emergency department visit or hospitalization for HF

Time frame: 90 days after inclusion

Delta weight

Delta weight (in kilograms) from admission to discharge

Time frame: From date of randomization until date of hospital discharge (regarding initial hospitalisation at time of randomisation, assessed up to 90 days)

Hospital length of stay

Number of days from hospitalization untill discharge or end of clinical treatment (not including days waiting for post-hospital care)

Time frame: Number of days from hospitalization untill end of clinical treatment (not including days waiting for post-hospital care) or hospital discharge, whichever came first, assessed up to 90 days after randomization.

Worsening renal function

Delta creatinine from baseline until discharge and 90 days follow-up

Time frame: Baseline until 90 days follow-up