The investigators conduct a random assignment into either the remimazolam group or the propofol group. Depending on the group assignment, either remimazolam (0.2 mg/kg) or propofol (1.0 mg/kg) is administered. If necessary, additional doses of remimazolam (0.1 mg/kg) or propofol (0.5 mg/kg) are given. The standard anesthesia procedure of our institution is followed, and blood pressure data recorded during the surgery is analyzed (mean arterial pressure \<65mmHg is defined as hypotension).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
112
Remimazolam is administered for anesthesia induction.
Propofol is administered for anesthesia induction.
Yonsei University College of Medicine
Seoul, South Korea
Hypotension occurrence (unit: number of patients)
"MAP\<65mmHg for 1 min
Time frame: during the total anesthesia duration
Amount of hypotension (unit: mmHg)
time-weighted average MAP \<65mmHg =\> depth of hypotension (mmHg) below a MAP of 65 mmHg \* time (min) below a MAP of 65 mmHg)/ total duration of surgery (min)
Time frame: during the total anesthesia duration
Vasopressor dose (unit: mcg for norepinephrine)
total dose of norepinephrine administered
Time frame: during the total anesthesia duration
Vasopressor dose (unit for vasopressin)
total dose of vasopressin administered
Time frame: during the total anesthesia duration
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