Human Milk Oligosaccharides (HMOs) are the third most abundant class of nutrients in human milk. Studies investigating the effects of dietary HMOs in infants have shown various health and developmental benefits such as the development of the early gut microbiome (by favouring colonisation of beneficial Bifidobacterium, Lactobacillus, and Bacteroides), the development of the immune system, general infant growth, protection against infectious diseases and allergies, and stimulation of cognitive development. Only a limited number of studies have been conducted in adults, showing intake of HMOs stimulates the growth of gut Bifidobacterium in healthy adults.
The current study aims to investigate the effects of a 4-week intervention with two HMOs on gut microbiome composition, immune function and gastrointestinal symptoms in healthy adults with mild to moderate gastrointestinal complaints. The study will be conducted as a partially decentralized, double-blind, randomized, placebo-controlled, parallel group design.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
108
Singapore Institute for Clinical Trials
Singapore, Singapore
Relative abundance of Bifidobacterium in the gut
Time frame: 4 weeks
Relative abundance of other bacterial taxa in the gut
Time frame: 4 weeks
Gut microbiome functional potential (functional metagenomics analyses)
Time frame: 4 weeks
Stool Human Milk Oligossacharides level
Time frame: 4 weeks
Concentration of immune parameters panel in blood (OLINK Target 96 Inflammation panel)
Time frame: 4 weeks
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