The goal of this exploratory n-of-1-study is to compare markers of metabolism in infants in a Level IV Neonatal Intensive Care Unit (NICU) between two lighting environments. Investigators are seeking to learn whether supplementing the lighting environment of infants in the NICU with blue and violet wavelengths of light will allow more efficient utilization of the nutrition provided to participants by influencing hormones involved in regulation of growth and development as compared to a conventional lighting environment. Pre-clinical studies suggest that violet and blue wavelengths of light are involved in molecular pathways that help regulate metabolic activity.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
32
Spectral room lighting containing violet and blue wavelengths of light capable of stimulating non-visual opsins including OPN5 and OPN3.
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
urine metabolomics
Urine samples will be collected and compared between lighting conditions for each infant utilizing high-resolution mass spectrometry-based proteomics and metabolomics for comprehensive analysis of networks and pathways influenced by SPEC exposure. We intend to target hormones known to be involved in metabolism and energy management, such as insulin, glucagon, adiponecting and leptin.
Time frame: For four weeks, clean urine will be collected with each diaper change, as possible.
temperature
body temperature as measured throughout the day, usually every 3-4 hrs
Time frame: For the duration of the participant's 4-week study timeline
heart rate
heart rate throughout the day, as collected every 3-4 hrs
Time frame: For the duration of the participant's 4-week study timeline
Phosphorus concentration
concentration of Phosphorus in serum (mg/dL)
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Magnesium concentration
concentration of Magnesium in serum (mg/dL)
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Calcium concentration
concentration of Calcium in serum (mg/dL)
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Sodium concentration
concentration of Sodium in serum (mmol/L)
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Potassium concentration
concentration of Potassium in serum (mmol/L)
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Chloride concentration
concentration of Chloride in serum (mmol/L)
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
glucose
glucose concentration in mg/dL
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Blood Urea Nitrogen
blood urea nitrogen concentration in mg/dL
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Creatinine
creatinine concentration in mg/dL
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Albumin
albumin concentration in gm/dL
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Total protein level
total protein concentration in gm/dL
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Alanine Aminotransferase (ALT)
Alanine Aminotransferase concentration in unit/L
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Aspartate Aminotransferase (AST)
Aspartate Aminotransferase (AST) concentration in unit/L
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Alkaline Phosphatase (ALP)
Alkaline Phosphatase (ALP) concentration in unit/L
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Gamma Glutamyl Transferase (GGT)
Gamma Glutamyl Transferase (GGT) concentration in unit/L
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Triglyceride
Triglyceride concentration in mg/dL
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Total Bilirubin
Total Bilirubin concentration in mg/dL
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
Direct Bilirubin
Direct Bilirubin concentration in mg/dL
Time frame: Typically collected twice-weekly for the duration of the participant's 4-week study timeline
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