In this study, the aim was to investigate the relationship between SII and other laboratory parameters with disease activity in AS patients and to discuss its usability in the follow-up and treatment process.
This study aimed to investigate the relationship between the systemic immune inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and disease activity and functional status in patients with ankylosing spondylitis (AS). A cross-sectional clinical study was conducted, and a total of 90 patients diagnosed with AS according to the Modified New York Criteria, aged between 18 and 65, who presented to our outpatient clinics were included in the study. Demographic data, disease duration, age at symptom onset, and laboratory parameters, including platelet, neutrophil, basophil, eosinophil, lymphocyte counts, mean platelet volume (MPV), red blood cell distribution width (RDW), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), were recorded. NLR and PLR values were calculated. The Systemic Immune Inflammation Index (SII) was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count. We investigated all of these parameters and disease activity scores. Disease activity was assessed with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), spinal mobility with the Bath Ankylosing Spondylitis Metrology Index (BASMI), and functional status with the Bath Ankylosing Spondylitis Functional Index (BASFI). In addition, during the routine follow-ups of patients, requested blood tests were examined, and platelet, neutrophil, basophil, eosinophil, lymphocyte counts, mean platelet volume (MPV), RDW (red blood distribution width), CRP, and ESR values will be recorded. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune inflammation index (SII) were calculated
Study Type
OBSERVATIONAL
Enrollment
90
No intervention
Istanbul Physical Therapy and Rehabilitation Research and Training Hospital
Istanbul, Bahcelievler, Turkey (Türkiye)
The Systemic Immune Inflammation Index (SII)
The Systemic Immune Inflammation Index (SII) was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count.
Time frame: through study completion, an average of 1 month
Neutrophil-to-lymphocyte ratio (NLR)
NLR is a ratio between the absolute neutrophil count and absolute lymphocyte count.
Time frame: through study completion, an average of 1 month
Platelet to-lymphocyte ratio (PLR)
PLR is a ratio between the absolute platelet count and absolute lymphocyte count.
Time frame: through study completion, an average of 1 month
Mean platelet volume (MPV)
MPV blood test measures the average size of patient's platelets
Time frame: through study completion, an average of 1 month
Red blood cell distribution width (RDW)
A red cell distribution width (RDW) test measures the differences in the volume and size of the red blood cells (erythrocytes).
Time frame: through study completion, an average of 1 month
C-reactive protein
C-reactive protein (CRP) is a protein made by the liver. The level of CRP increases when there's inflammation in the body.
Time frame: through study completion, an average of 1 month
Erythrocyte sedimentation rate
The erythrocyte sedimentation rate (sedimentation rate, sed rate, or ESR for short) is a commonly performed hematology test that may indicate and monitor an increase in inflammatory activity within the body caused by one or more conditions such as autoimmune disease, infections, or tumors
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Time frame: through study completion, an average of 1 month
The Bath Ankylosing Spondylitis Disease Activity Index
The index indicates that disease activity of AS patients. Higher scores indicate that higher activity
Time frame: through study completion, an average of 1 month
The Bath Ankylosing Spondylitis Functional Index
The index helps to evaluate disease activity of AS patients. High scores indicate that worse functional status.
Time frame: through study completion, an average of 1 month
The Bath Ankylosing Spondylitis Metrology Index
The index helps to evaluate spinal mobility of AS patients. Higher scores indicate more limited mobility.
Time frame: through study completion, an average of 1 month
Ankylosing Spondylitis Disease Activity Score with erythrocyte sedimentation rate
it helps to evaluate disease activity of AS patients by used to esr
Time frame: through study completion, an average of 1 month
Ankylosing Spondylitis Disease Activity Score with c-reactive protein
it helps to evaluate disease activity of AS patients by used to crp
Time frame: through study completion, an average of 1 month