DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study

Queen Mary Hospital, Hong Kong49 enrolled

Overview

To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Extracorporeal Circulation; Complications Extracorporeal Membrane Oxygenation Complication

Interventions

DIC markers and Thrombin Generation ParametersDIAGNOSTIC_TEST

Observation of DIC markers and thrombin generation parameters in patients with and without thrombotic and hemorrhagic complications

Eligibility

Sex: ALLMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≧ 18; AND * Admitted to the mixed medical-surgical intensive care units of Queen Mary Hospital or Tuen Mun Hospital in Hong Kong; AND * Require either veno-arterial (VA) or veno-venous (VV) extracorporeal membrane oxygenation (ECMO) support. Exclusion Criteria: * Patients who are on central VA-ECMO support; OR * Patients with missing clinical data; OR * Patients with pre-existing thromboembolism requiring long term anticoagulation prior to ECMO cannulation; OR * Post-operative admissions

Locations (1)

Queen Mary Hospital

Hong Kong, Hong Kong

Outcomes

Primary Outcomes

Composite of thrombotic and hemorrhagic events

Thrombotic events include circuit-related thrombosis (e.g. oxygenator failure requiring circuit change) OR Non-circuit-related thrombosis (e.g. new pulmonary embolism or deep vein thrombosis while on ECMO. Hemorrhagic events include bleeding at critical sites or requiring interventions.

Time frame: From the start of ECMO support to the end of ECMO support (which can be variable, typically around 5 days to 1 week)

Data from ClinicalTrials.gov

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