Enhanced Recovery After Surgery for SPK Transplantation Recipients

Second Affiliated Hospital of Guangzhou Medical University90 enrolled

Overview

108 patients underwent elective SPK surgery were randomly divided into ERAS group (E) and routine care group (T). The ERAS group was consisted of evidenced-based systematic optimization approaches, while the control group received routine care.

Primary results: the postoperative length of stay (LoS) and hospitalization costs; second results: post-operative analgesia score (NRS) , the incidence of post-operative nausea and vomiting (PONV) , urinary catheter removal time by 7 days , post-operative gastric tube indwelling time, the incidence of ambulation within 6 days . the dosage of dobutamine using , the dosage of norepinephrine using, and the total amount of fluid and urine volume . MAP and lactate level . Peak systolic velocity (PSV) and (resistance index) RI of grafts were checked between two groups.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

QUADRUPLE

Enrollment

Conditions

Transplant Complication Diabetic Nephropathy Perioperative/Postoperative Complications

Interventions

Enhanced recovery for SPK recipientsPROCEDURE

Pre-operative, perioperative and post-operative were consisted of evidenced-based systematic optimization approaches.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 62 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients were aged 20-62 years 2. Body mass index (BMI) of 18.5-32.9 kg/m2 3. Voluntary participation for elective SPK surgery 4. ERSD and DN patients waiting for SPK transplantation surgery. Exclusion Criteria: 1. History of allergy to narcotic drugs 2. cardiopulmonary insufficiency 3. congestive heart failure 4. myasthenia gravis 5. neurological disease 6. mental illness 7. severe liver dysfunction 8. hyperkalaemia 9. malignant hyperthermia 10. unwilling to participate in the study for any reason, or had participated in another study within the 3 months

Locations (1)

Second affiliated hospital of Guangzhou Medical University

Guangzhou, Guangdong, China

Outcomes

Primary Outcomes

Length of hospital stay (LoS)

Record the time for SPK recipients of LoS (days)

Time frame: Record all the period time from the day of admiting to hospital to the day of discharge from hospital(days).

Hospital costs (US dollar)

The total cost of treatment for the patients.

Time frame: Total costs(dollar) of the patients spended from the day of admiting to hospital to the day of discharge from hospital(days).

Secondary Outcomes

Perioperative complications

48 hours post-operative analgesia score (NRS), the incidence of post-operative nausea and vomiting (PONV) , urinary catheter removal time by 7 days , post-operative gastric tube indwelling time, the incidence of ambulation within 6 days

Time frame: After the surgery acomplishment(see detail above)：record the NRS within 40hours after the surgery, occurrence rate of the PPCs within 2 weeks after the surgery, ocurrence rate of the ambulation within 6 days after the surgery, etc.

Data from ClinicalTrials.gov

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