This study is a double-blind randomized vehicle-controlled study assessing how Zinc Di-(dibutyryl lisinate) (Z-DBL) influences skin biophysical measures such as skin hydration, transepidermal water loss, and elasticity, as well as its effects on the skin microbiome of photoaged skin.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Enrollment
46
Instructions: Apply to the entire face twice daily - morning and evening
Instructions: Apply to the entire face twice daily - morning and evening
Integrative Skin Science and Research
Sacramento, California, United States
Change in image analysis based pigment intensity
Facial photographs will be analyzed for pigment intensity for the face after the photographs are obtained and analyzed utilizing the BTBP 3D Clarity Pro Facial Modeling and Analysis System (Brigh-Tex BioPhotonics, San Jose, CA, USA). The pigment intensity will be measured as a relative change from baseline and is a dimensionless and normalized measure.
Time frame: 8 weeks
Skin Hydration
The skin capacitance will be measured with a handheld non-invasive device (Skin MoistureMeterSC, Delfin Technologies Ltd.). The measurement is in arbitrary units per manufacturer.
Time frame: 8 weeks
Change in image analysis based wrinkle severity
Facial photographs will be obtained and analyzed utilizing the BTBP 3D Clarity Pro Facial Modeling and Analysis System (Brigh-Tex BioPhotonics, San Jose, CA, USA). The measurement will analyze wrinkle severity that is a measure of both the wrinkle depth and width and will be reported as a relative change from baseline.
Time frame: 8 weeks
Shifts in the skin microbiome diversity
Whole genome sequencing of the skin microbiome
Time frame: 8 weeks
Changes in skin barrier biomarkers like filaggrin
Measured using D-squame tape strips (CuDerm LLC.)
Time frame: 8 weeks
Product tolerability
Assessed with the use of a tolerability questionnaire to be completed by participants. Tolerability will be measured by rating symptoms such as burning, stinging, and scaling.
Time frame: 8 weeks
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Change in skin elasticity
Skin elasticity measured with a handheld non-invasive device (Elastimeter, Delfin Technologies Ltd.)
Time frame: 8 weeks
Change in skin transepidermal water loss
Skin transepidermal water loss measured with a handheld non-invasive device (Vapometer, Delfin Technologies Ltd.)
Time frame: 8 weeks