Potassium Copetitive Acid Blockers Efficacy in H.Pylori Eradication

Ain Shams University232 enrolled

Overview

This trial assessed the efficacy of potassium competetor acid blocker (P-CAB) in the eradication of H.pylori

The aim of this study is to compare the effectiveness of Vonaprazan based therapy vs.Proton Pump Inhibitor (PPI)based therapy for the eradication of H.Pylori infection in treatment naive and treatment experienced Egyptian patients.This prospective, non- randomized, controlled study was conducted on symptomatic patients admitted at Tropical Medicine Department at Ain Shams University Hospitals and those presenting at outpatient clinic. The study was conducted in the period from the 1st of January 2022 to the 1st of June 2023.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

232

Conditions

Helicobacter Pylori Eradication

Interventions

VonoprazanDRUG

Venoprazan 20mg twice daily,clarithromycin 500mg twice daily,amoxycillin 1 gm twice daily,esomeprazole 20mg twice daily,levofloxacin 500mg a single tablet daily,doxycicline 100mg a single capsule daily and nitazoxanide 500mg twice daily

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age above 18 years of both genders. * Symptomatic patients who has been diagnosed to be H. pylori positive stool by using H. pylori stool antigen test. * Patients who did not receive H. pylori eradication regimens before were included in group I of the study (First line eradication regimen). * Patients who received only one eradication regimen before were included in group II of the study (Second line eradication regimen). * Patients signing an informed consent. Exclusion Criteria: * Patients refusing to sign an informed consent. * Patients who were on PPIs, P-CABs and/or antibiotics starting one month before inclusion in the study . * Patients who have chronic debilitating and advanced systemic diseases. * Patients treated with low dose aspirin and/or non-steroidal anti-inflammatory drugs for a long time. * Any lactating or pregnant female.

Locations (1)

Faculty of Medicine Ain Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

H.pylori eradication

The rate of the patients who achieved H.pylori eradication as measured by negative H.Pylori stool antigen test in the four arms of the study was reported.

Time frame: six weeks

Secondary Outcomes

Safety of Vonoprazan use

The number of patients who reported minor and major treatment connected adverse events in the four arms of the study was reported.

Time frame: six weeks

Data from ClinicalTrials.gov

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