Sarcopenia is a complex multifactorial syndrome which could be present in older age (primary sarcopenia) or earlier in chronic disease (secondary sarcopenia). Even if in patients with chronic liver disease an association among sarcopenia and poor clinical outcomes is well known, the data available about the prevalence of sarcopenia in patients with liver cirrhosis, non-alcoholic fatty liver disease and hepatocellular carcinoma are very variable according to the populations in object and, furthermore, few data are available regarding the use of muscular ultrasound to detect this condition. The aim of this study is to define the prevalence of sarcopenia in patients with liver cirrhosis, non-alcoholic fatty liver disease and hepatocellular carcinoma in follow-up at our center and the clinical outcomes associated with this condition, and to determine the reliability of muscular ultrasound to diagnose the condition of sarcopenia through a comparison with other validated techniques such as computed tomography, magnetic resonance imaging and dual-energy X-ray absorptiometry.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
125
A handgrip strength test using a hydraulic hand dynamometer will be performed
A total body Dual Energy X-Ray Absorptiometry (DXA) to estimate muscle mass will be performed
A muscular ultrasound of abdominal muscles, forearm muscles, quadriceps and gastrocnemius will be performed
CEMAD
Roma, RM, Italy
RECRUITINGTo calculate the prevalence of the condition of sarcopenia in patients with liver cirrhosis, non-alcoholic fatty liver disease and hepatocellular carcinoma
Time frame: 24 months
Association among sarcopenia and survival or acute decompensation events in patients with liver cirrhosis
Time frame: 24 months
To calculate the prevalence of obesity with sarcopenia in patients with non-alcoholic fatty liver disease
Time frame: 24 months
To evaluate the association among sarcopenia and therapeutic response in patients with hepatocellular carcinoma
Time frame: 24 months
To calculate cohen's Kappa to evaluate the concordance among muscular ultrasound and dual-energy X-ray absorption, computed tomography scan and magnetic resonance imaging in the detection of sarcopenia
Time frame: 24 months
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