A patient with oncological pathology of any type because of impaired digestion and nutrient absorption, decreased intake, and increased nutrition requirements has an increased risk of malnutrition and moderate to severe weight loss.In the present study the investigators will evaluate the impact of perioperative immunonutrition supplementation on the postoperative outcomes.
Malnutrition has a major effect not only on the postoperative course of cancer surgery but can also complicate or even limit administration or compromise the effectiveness of other treatments such as chemotherapy or radiotherapy in the perioperative period. Immunonutrition is a type of artificial nutrition based on the use of some types of macro- or micronutrients.The purpose of this review was to evaluate the use, indications, and effects of these formulas in oncologic surgical patients in real time and to identify the types of patients who can benefit from enteral immunonutrition.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
200
enteral supplementation with high amount of proteins, arginine, glutamine, nonessential fatty acids, branched chain fatty acids, nucleotides, or RNA
First department of Obstetrics and Gynecology
Athens, Greece
RECRUITINGPerioperative infections
We will notice possible surgical site infections,respiratory inflammations etc and calculate inflammatory markers and the concentration of white blood cells
Time frame: Postoperatively (30 days)
Duration of hospitalization
From date of hospitalization until the date of discharge or date of death from any cause, whichever came first, assessed up to 2 months.
Time frame: Until discharge from hospital
Postoperative mobilization
From date of surgery until the date of discharge or date of death from any cause, whichever came first, assessed up to 2 months.
Time frame: Until first day of mobilization
Postoperative morbidity (other than infectious)
Major events such as pulmonary embolism,accuse myocardial infarction,etc
Time frame: 30 days
Recurrence rates
Recurrent disease will be monitored through 3 year of follow up
Time frame: 3 years follow-up
Overall survival
Overall survival of the patients will be measured through 3 year of follow up
Time frame: 3 years follow-up
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