The aims of this study are two-fold. First to investigate the influence of protein on the FGF21 response induced by alcohol, and second to investigate the influence of retinol on FGF21 concentrations and the FGF21 response induced by alcohol. Exploratory, and in order to investigate mechanisms behind the potential influence on alcohol-induced FGF21 response from protein or retinol intake, plasma glucose, insulin, glucagon, ethanol, acetaldehyde, acetate, retinol, retinoic acid, as well as subjective rating of appetite, will be measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
31
Test drink with 12 g alcohol (30 g vodka 40%) in water
Test drink with 12 g alcohol (30 g vodka 40%) and 25 g whey protein in water
Test drink with 12 g alcohol (30 g vodka 40%) and 1000 μg retinol in water
Departmen of Nutrition, Exercise and Sports
Copenhagen, Denmark
Plasma FGF21 response after consumption of alcohol+protein vs alcohol
Time\*drink interaction and iAUC
Time frame: Outcomes are measured at time 0, 30, 60, 120, 180, and 240 minutes after test drinks.
Plasma FGF21 response after consumption of alcohol+retinol vs alcohol vs retinol
Time\*drink interaction and iAUC
Time frame: Outcomes are measured at time 0, 30, 60, 120, 180, and 240 minutes after test drinks.
Plasma glucose, insulin, glucagon, ethanol, acetaldehyde, acetate, retinol, and retinoic acid after consumption of alcohol+protein vs alcohol+retinol vs alcohol vs retinol.
Time\*drink interaction and iAUC
Time frame: Outcomes are measured at time 0, 30, 60, 120, 180, and 240 minutes after test drinks.
Subjective appetite ratings after consumption of alcohol+protein vs alcohol+retinol vs alcohol vs retinol.
Time\*drink interaction and iAUC
Time frame: Outcomes are measured at time 0, 30, 60, 120, 180, and 240 minutes after test drinks.
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Test drink with 1000 μg retinol in water