The purpose of this study is to see how rabeprazole affects the level of the study medicine sisunatovir in the blood of healthy adult participants. Rabeprazole is a medicine that reduces the amount of acid the stomach makes. The information from this study may inform how sisunatovir will be used in the future with medicines that reduce stomach acid. This study is seeking healthy participants who: * are aged 18 years of age or older. * are confirmed to be healthy by some medical tests. This study can include both men and women. Women who can produce a baby must agree to use a highly effective method of birth control. * have body mass index (BMI) of 16 to 32 kilograms per meter squared. * a total body weight of more than 45 kilograms. Participants will receive sisunatovir tablets by mouth on Day 1. After at least 48 hours, participants will take rabeprazole tablets by mouth once a day for 7 days. On the last (7th) day of rabeprazole dosing, another dose of sisunatovir tablets will be taken by mouth. The study will look at the blood levels of sisunatovir with and without taking rabeprazole. This will help see how sisunatovir should be given in the future. The total planned time of participation is about 10 to 11 weeks. The study consists of: * screening period of up to 28 days before taking sisunatovir. * 13 days of staying in the study clinic. * a follow-up contact that will occur 28 to 35 days after taking sisunatovir the last time.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
40
Single Dose
Tablets once daily for 7 days
Tablets once daily for 7 days
Tablets once daily for 7 days
Pfizer Clinical Research Unit - Brussels
Brussels, Bruxelles-capitale, Région de, Belgium
Maximum Observed Plasma Concentration (Cmax)
Time frame: 0 to 72 hour postdose
Area Under the Curve From Time Zero to Extrapolated Infinite Time (AUCinf)
AUCinf = Area under the plasma concentration versus time curve (AUC) from time zero (pre-dose) to extrapolated infinite time (0-inf). It is obtained from AUC (0-t) plus AUC (t-inf).
Time frame: 0 to 72 hours postdose
Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast)
Area under the plasma concentration time-curve from zero to the last measured concentration (AUClast)
Time frame: 0 to 72 hours postdose
Number of Participants With Treatment Emergent Treatment-Related Adverse Events (AEs)
Time frame: Baseline up to 35 days after last dose of study intervention
Number of Participants With Clinical Laboratory Abnormalities
Time frame: Baseline to Study Day 12 (Part 1) or Study Day 20 (Part 2)
Number of Participants With Clinically Significant Change From Baseline in Vital Signs
Time frame: Baseline to Study Day 12 (Part 1) or Study Day 20 (Part 2)
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