Testosterone and Vascular Function in Reproductive-Aged Females With Chronic Kidney Disease

University of Calgary61 enrolled

Overview

Cardiovascular disease (CVD) is the leading cause of death among women and women with chronic kidney disease are at an even greater risk of CVD. The aim of this observational study is to examine the relationship between total testosterone levels and measures of vascular function (pulse wave velocity, aortic augmentation index, flow mediated dilation and velocity time integral) in reproductive-aged women living with chronic kidney disease.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Kidney Diseases Cardiovascular Diseases

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 51 Years

Medical Language ↔ Plain English

Inclusion Criteria: * female sex * a diagnosis of chronic kidney disease or end stage kidney disease * age 18-51 Exclusion Criteria: Pregnancy, breastfeeding, current use of menopausal hormone therapy or gender affirming hormone therapy, or factors that would affect ovarian function, such as polycystic ovarian syndrome, premature ovarian insufficiency, ovarian malignancy, gonadotoxic chemotherapy, surgical oophorectomy, or previous radiation to the pelvis.

Locations (1)

University of Calgary

Calgary, Alberta, Canada

Outcomes

Primary Outcomes

Pulse wave velocity

Time frame: Measured at baseline

Aortic augmentation index

Time frame: Measured at baseline

Flow mediated dilation

Time frame: Measured at baseline

Velocity time integral

Time frame: Measured at baseline

Data from ClinicalTrials.gov

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