The aim of this research study is to look at the body composition (such as muscle and fat) in people with chronic kidney disease (CKD) and comparing it with body composition is people without CKD. The investigators currently understand loss of muscle function and mass (sarcopenia) affect the general health of people as they age, but this process seems to be more common, accelerated, and occurs earlier in people with CKD. There is limited evidence in this area, and we believe that if we understand when and how sarcopenia affects people with CKD, investigators can guide future trials and treatments to help treat sarcopenia, and in turn improve quality of life and health outcomes in people with CKD.
In this study, the investigators will follow up people with CKD in two visits a year apart. In both visits, the investigators will measure the participants body composition and estimated kidney function using 2 different testing methods - Cystatin C eGFR and Creatinine eGFR. Using both the results in a formula, the creatinine muscle index can be calculated. If this index correlated with sarcopenia, it will be helpful tool in the care of people with CKD as will be a easy to use screening tool for sarcopenia in this population.
Study Type
OBSERVATIONAL
Enrollment
80
Cystatin C eGFR is not used routinely currently in clinical practice in the UK. It involved a blood test to analyse Cystatin C.
Participants will stand on a bioimpedance analysis machine which will measure different components of body composition
University Hospitals of Derby and Burton NHS Foundation Trust
Derby, United Kingdom
Creatinine Muscle Index (mg/day per 1.73m2)
Product of serum Creatinine and estimated glomerular filtration rate with Cystatin C (eGFRcys)
Time frame: Day 1 (day recruited) and at 1 year
Skeletal muscle mass (kg)
Measured by Bioimpedance analysis
Time frame: At Day 1 (day recruited) and 1 year
Multimorbidity Score
The Cambridge Multimorbidity Score is a UK validated index to score the comorbidities of participants. One can score from 0 to 20 on this index. Higher scores are associated with worse clinical outcomes.
Time frame: Day 1 (day recruited) and 1 year
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