Safety and Tolerance Study of IBI355 in Health Volunteers

Inclusion Criteria: 1. Subjects who have decided to voluntarily participate in the study and provided a written consent regarding observance of precautions after having been informed of and having fully understood the objectives, methods, and effects of the study in detail; 2. Healthy male and female aged 18 years or above ; 3. Subject with a Body Mass Index (BMI)\* between 18.5 and 28.0 kg/㎡; 4. subjects with a normal laboratory examination，ECG， X-ray. Exclusion Criteria: 1. Subjects with a history of allergy； 2. Subjects participated in the other clinical trail in 1 month or less than 5 t1/2 since the previous clinical trial (which is longer)； 3. Subjects with an infection requiring systemic medication was present within 30 days prior to randomization; 4. HIV-Ab、RPR、HCV-Ab、HBV、HBeAg or HBcAb, one of them positive; 5. There have a clinical or imaging evidence that the subject with active tuberculosis, or there is evidence that the subject is in the incubation period for tuberculosis; 6. Patients with a history of central nervous system, cardiovascular system, digestive system, respiratory system, urinary system, blood system, metabolic disorders and other systemic diseases; 7. Subject with a hcg positive; 8. Patients with a history of neuropsychiatry or who are considered unfit to participate in this clinical trial