Evaluation of the Consequences of Poly Vaccination on Innate Immunity : Applications to a Military Population

N/ANot Yet RecruitingNCT06110741

Direction Centrale du Service de Santé des Armées410 enrolled

Overview

In this study, the poly vaccination of military personnel prior to deployment will be analyzed in terms of central, peripheral and long-lasting changes in innate immunity. Analysis of monocyte immune training induced by vaccination will provide a better understanding of the indirect effects of vaccination and their persistence over time.

Study Type

OBSERVATIONAL

Enrollment

410

Conditions

Vaccine Breakthrough Infections

Interventions

Blood and saliva samplingOTHER

Collecting blood and saliva sample

SurveyOTHER

Collecting data on infectious diseases during the study period

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * french military personnel * \>18yo * overseas deployment scheduled between 30 and 60 days after vaccination session * adult * able to give consent Exclusion Criteria: * unrectified military personnel * having received a live vaccine within 6 months prior to inclusion * having received an attenuated vaccine within 3 months prior to inclusion * pregnancy or breastfeeding * vaccine contraindication * major incapacity

Outcomes

Primary Outcomes

Monocytes' functional reprogramming

describing the functional reprogramming of monocytes following vaccination sessions among military personnel prior and after deployment

Time frame: 11 months

Secondary Outcomes

Identify immune signatures

Identifying immune signatures by comparing the functional reprogramming of monocytes by different vaccines and co vaccinations schemes

Time frame: 11 months

Time persistence

Assess the persistence over time of the effects by follow-up after return from mission

Time frame: 11 months

Data from ClinicalTrials.gov

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