The aim of this study to evaluate the effect of preemptive oral gabapentin versus tramadol on postoperative pain after knee arthroscopy under spinal anesthesia.
Orthopedic surgeries are frequently associated with moderate-to-severe postoperative pain that can decrease mobility in the immediate postoperative period, interfere with postoperative rehabilitation, and delay hospital discharge. Pain may also become chronic. Spinal anesthesia is the most popular anesthesia technique worldwide in orthopedic lower limb surgeries. However, its relatively short duration of action may limit the excellent postoperative analgesic effect. Thus, many adjuvants had been used to improve postoperative analgesia and decrease consumption of postoperative analgesics. Gabapentin is a gamma aminobutyric acid analogue that is known as an anticonvulsant drug. This drug is tolerated well and has known effects on pain and anxiety. Tramadol, a commonly used postoperative analgesic, is a synthetic centrally acting opioid analgesic. The various actions include inhibition of noradrenaline and serotonin reuptake, and also inhibition of M1 and M3 muscarinic receptors
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
50
Patients will receive oral gabapentin 600 mg 1 hour before the surgery.
Patients will receive oral tramadol 100 mg 1 hour before the surgery.
Tanta University
Tanta, El-Gharbia, Egypt
The intensity of postoperative pain
Assessment of postoperative pain will be done with a analogue scale (VAS; 0=no pain and 10=worst possible pain). At discharge post-operative and every 2 hours postoperative till 12hours then every 6 hours for the first 24 hours.
Time frame: 24 hours postoperatively
The total amount of morphine consumption in the first 24-hour postoperative
Rescue analgesia in the form of 3 mg of IV morphine will be given if the visual analog scale (VAS) score\> 3.
Time frame: 24 hours postoperatively
The time first rescue analgesia
Rescue analgesia in the form of 3 mg of IV morphine will be given if the visual analog scale (VAS) score≥ 4.
Time frame: 24 hours postoperatively
The incidence of side effects
Any undesirable side effects during the first 24 hours will be recorded such as as nausea, vomiting \&hypotension.
Time frame: 24 hours postoperatively
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