Evolution of Vestibular Function After Treatment of a Vestibular Schwannoma by Gamma-knife Radio-surgery

Centre Hospitalier Universitaire de Besancon20 enrolled

Overview

The purpose of this study is to evaluate the vestibular effects of gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.

Vestibular schwannoma is a benign tumor located on the vestibulocochlear nerve. It represents 6 to 8% of intracranial tumors, 80% of ponto-cerebral angle tumors and its frequency is 13 cases per million inhabitants per year. The main symptoms related to the development of vestibular schwannoma are unilateral deafness of perception, unilateral tinnitus, unilateral vestibular deficit vertigo, facial paralysis. Management is divided into 3 options: monitoring, surgery and gamma-knife radiosurgery. This study will focus on gamma-knife radiosurgery. The objective of this treatment is to stabilize the evolution of schwannoma. This study aims to describe the vestibular effects of radiosurgery.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Vestibular Schwannoma Neurinoma, Acoustic Acoustic Neuroma

Interventions

Vestibular examOTHER

Interrogation, videonystagmoscopy, videonystagmography, video-head-impulse-test

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria : * Men and women aged 18 to 90 included * Subject who benefited from gamma-knife radiosurgery as part of the treatment of vestibular schwannoma * Non-opposition of the subject to participate in the study * Affiliation to a French social security scheme or beneficiary of such a scheme Exclusion Criteria : * Subject with another vestibular pathology * Subject who did not benefit from a vestibular assessment before treatment with gamma-knife radiosurgery * Legal incapacity or limited legal capacity * Subject unlikely to cooperate in the study and/or weak cooperation anticipated by the investigator * Subject without health insurance * Subject being in the period of exclusion from another study or provided for by the "national volunteer file".

Locations (1)

CHU de Besançon

Besançon, France

RECRUITING

Outcomes

Primary Outcomes

Description of vestibular function with videonystagmography before gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.

Videonystagmography: Results of caloric tests = Intervestibular deficit (in percentage)

Time frame: 1 month before gamma-knife radiosurgery

Description of vestibular function with vidéonystagmoscopy before gamma-knife radiosurgery, as part of the treatment of vestibular schwannoma.

Videonystagmography: Results of caloric tests = Intervestibular deficit (in percentage)

Time frame: After gamma-knife radiosurgery at 6 month or 12 month or 18 month or 2 years or 3 years depending on the history of the treatment

Secondary Outcomes

Description of vestibular symptoms before gamma-knife radiosurgery as part of the treatment of vestibular schwannoma.

Dizziness Handicap Inventoryquestionnaire (DHI questionnaire)

Time frame: 1 month before gamma-knife radiosurgery

Description of vestibular symptoms after gamma-knife radiosurgery as part of the treatment of vestibular schwannoma.

Dizziness Handicap Inventoryquestionnaire (DHI questionnaire)

Time frame: After gamma-knife radiosurgery at 6 month or 12 month or 18 month or 2 years or 3 years depending on the history of the treatment

Central Contacts

Mylene ABISSE, MD

CONTACT

+33381218988 mabisse@chu-besancon.fr

POZET Astrid

CONTACT

+33381218988 apozet@chu-besancon.fr

Data from ClinicalTrials.gov

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