Stroke is a leading and growing cause of long-term adult disability. Up to 80% of stroke patients have impaired manual dexterity reducing their independence, return to work and quality of life. Cognitive impairment is also common after stroke and growing evidence suggests a cognitive-motor interdependence with relevance for motor recovery. Previous studies show increased cognitive-motor interference (measured in dual-task) in stroke patients and that combining motor and cognitive task training (in a dual-task) may improve motor function above that achieved by single-task training. This project addresses post-stroke dexterity impairment and its relation to dual-task interference, i.e., the decrease in motor performance when performing a concurrent cognitive task. The overall goal is to provide a proof-of-concept for a dual-task interference training protocol post-stroke. We aim to establish therapeutic efficacy of dual-task vs single-task dexterity training in chronic stroke patients.Single-task training involves visuomotor finger force tracking and dual-task has an additional cognitive components including visual distraction and working memory. Training will be done 4 days/week over four weeks (total 16 sessions). Each session will include 20 mins of conventional therapy (stretching, functional exercises) followed by 40 mins motor task training (either single or dual task). This pilot randomized clinical trial will include 40 stroke patients (\> 6 months after stroke). Repeated clinical and fine-grained motor measurements will be obtained pre and post intervention and at 3 months follow-up.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
Single-task training involves visuomotor finger force tracking and dual-task has an additional cognitive components including visual distraction and working memory.
Danderyd Hospital, Division of Rehabilitation Medicine, Dept. of Clinical Sciences, Karolinska Institutet
Stockholm, Danderyd, Sweden
Department of Rehabilitation Medicine, Danderyd Hospital
Danderyd, Stockholm County, Sweden
Fugl-Meyer Assessment change (FMA change)
Assesses sensory and movement related functions in the upper extremity (0 points max impairment summed up to 66 points max no detected impairment)
Time frame: At baseline and at 3 to assess change.
Box and Block change (BBT change)
Assesses gross dexterity by timing how many blocks can be grasped and displaced in one minute (measured as blocks/min)
Time frame: At baseline and at 3 to assess change.
Logical reasoning change (WAIS IV matrices change)
Assesses intelligence through four composite socres: verbal comprehension, perceptual reasoning, working memory and processing speed (scored from 45 to 155).
Time frame: At baseline and at 3 to assess change.
Attention change (D-KEFS trail making test 1-5)
Trail making test assesses attention capacites in five conditions: visual scanning, number sequencing, letter sequencing, number-letter sequencing, and motor speed (the speed of each condition is noted in seconds, max 150seconds).
Time frame: [At baseline and at 3 to assess change.
Executive function change (D-KEFS FAS, D-KEFS tower)
Assesses executive function capacities such as spatial planning, rule learning, inhibition of impulsive responding, inhibition of perseverative responding, and establishing and maintaining instructional set. Scoring: raw scores are converted to scaled scores through established age and gender normative data, Mean=10, standard deviation=3).
Time frame: At baseline and at 3 to assess change.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.