Comparison of Pre-operative EUS Guided and Intra-operative Direct Portal Vein Pressure Measurement in Pretransplant Cirrhotics

Asian Institute of Gastroenterology, India25 enrolled

Overview

Direct portal pressure measurement under EUS-guidance (EUS-PPM) is a promising alternative to conventional indirect Hepatic Venous Pressure Gradient (HVPG). In patients undergoing liver transplantation for cirrhosis, high pre-operative portal vein (PV) pressure requires intra-operative portal vein inflow modulation (PIM). This pilot study aims to assess correlation between EUS-PPM with direct intra-operative portal pressure measurement (IO-PPM).

Study Type

OBSERVATIONAL

Enrollment

Conditions

Liver Cirrhosis

Interventions

EUS Portal pressure measurementPROCEDURE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Liver cirrhosis patients scheduled for liver transplant for the standard indications within next 24- 48 hours will be included. Exclusion Criteria: * Severe ascites not amenable for tapping * History of blood thinner consumption within last 5 days * Active duodenal ulcerations

Outcomes

Primary Outcomes

Correlation between EUS-PPM with direct intra-operative portal pressure measurement (IO-PPM).

Time frame: 1 year

Secondary Outcomes

Correlation between readings of EUS-PPM using portable manometry set and arterial transducer.

Time frame: 1 year

Data from ClinicalTrials.gov

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