Resistance Training on Growth Factors

Air Force Military Medical University, China12 enrolled

Overview

The goal of this clinial trial study is to explore the effect of high or low intensity resistance training (LIRT) under similar training volume on change in serum levels of BDNF, IGF-1, VEGF, irisin, and plasma Hcy in young adults.The main questions it aims to answer are: 1. Whether high and low intensity will increase the serum levels of BDNF, IGF-1, VEGF, irisin, and reduce plasma Hcy. 2. whether a greater magnitude of change would be suffer in low intensity group when compared to high intensity group, as an effect of greater physiological adaptation produced by more repetitions required to complete. Participants will performe two different intensity resistance training (HIRT, at 80%1RM with 12 repetitions and 4-5 sets and LIRT, at 40%1RM with 24 repetitions and 4-5 sets). Researchers will compare the training effects of two different training on these growth factors.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Cognitive Function

Interventions

Low intensity resistance trainingOTHER

For LIRT protocol, which performed same training exercises as HIRT. The repetitions in the LIRT protocol were assessed using the following equation: 80% of 1RM lifting load (kg) ×repetitions (HIRT)/40% of 1RM to volition fatigue, with 1-2 minutes of rest period between sets. Therefore, the LIRT protocol completed 4-5 sets of 24 repetitions at 40% of 1RM for a total of 60 minutes.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * age between 18 to 30 years * no experiencing musculoskeletal disorders or sports injuries * had not participated any regular aerobic endurance or resistance training with in the previous half years * no smoking habit or intake alcohol and other medication (e.g., steroid hormone) * good general body condition without any chronic diseases (e.g., osteoarthritis, metabolic syndrome or arthritis) Exclusion Criteria: * experiencing musculoskeletal disorders or sports injuries in recent 1 month * had regular resistance training exercise * intake any supplementary(drug and hormone)

Outcomes

Primary Outcomes

Rata of perceived exertion

The rating of perceive exertion (RPE) questionnaire scale was applied to assess participants' subjective fatigue feeling throughout the training period.