The goal of this clinical trial is to evaluate the effects of Cannabigerol (CBG) on indicators of Attention-Deficit/Hyperactivity Disorder (ADHD) in a sample of participants indicating/reporting symptoms associated with ADHD. The main question it aims to answer is: Does CBG reduce ADHD-related indicators relative to placebo? Participants will administer an acute dose of placebo or 80mg CBG and complete outcome measures at 45 minutes and 75 minutes. Daily surveys to monitor safety will be administered for one week following administration.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
76
1 mL of 80mg Cannabigerol once during experimental session
1 mL of placebo once during experimental session
University of Arkansas
Fayetteville, Arkansas, United States
RECRUITINGSustained Attention to Response Task
A computerized task that measures response inhibition.
Time frame: 75 minutes post CBG/placebo administration
Trail Making Test-Parts A and B (TMT-A&B)
A paper-and-pencil task that measures
Time frame: 75 minutes post CBG/placebo administration
Digit Symbol Substitution Test (DSST)
A paper-and-pencil task that measures attention/processing speed.
Time frame: 75 minutes post CBG/placebo administration
Rey Auditory Verbal Learning Test (AVLT)
A paper-and-pencil/verbal test that measures verbal memory.
Time frame: 75 minutes post CBG/placebo administration
Iowa Gambling Task (IGT)
A computerized task that measures decision making (an indicator of impulsivity/hyperactivity).
Time frame: 75 minutes post CBG/placebo administration
Positive and Negative Affect Scale-Expanded Version
Self-report measure of positive and negative affect. Scores range from 30-150 on each of the two types of affects, with higher scores representing greater affect.
Time frame: Baseline, 45 minutes post CBG/placebo administration, 75 minutes post CBG/placebo administration
Karolinska Sleepiness Scale
Self-report measure of subjective level of sleepiness at a particular time during the day. Scores range from 1-10, with higher scores representing greater sleepiness.
Time frame: Pre CBG/placebo administration, 75 minutes post CBG/placebo administration
Brief Irritability Test
Self-report measure of irritability. Scores range from 5-30, with higher scores representing greater irritability.
Time frame: Pre CBG/placebo administration, 75 minutes post CBG/placebo administration
Numeric Rating Scale (pain)
Self-report measure of subjective level of pain. Scores range from 0-10, with higher scores representing greater pain.
Time frame: Pre CBG/placebo administration, 75 minutes post CBG/placebo administration
State-Trait Anxiety Inventory (State Version)
Self-report measure of state anxiety. Scores range from 20 to 80 with higher scores indicating greater anxiety.
Time frame: Pre CBG/placebo administration, 75 minutes post CBG/placebo administration
Visual Analog Scales
Self-report of state-like states (e.g., anxiety, hunger). This scale ranges from 0 to 100 with higher scores indicating higher levels of the indication.
Time frame: 75 minutes post CBG/placebo administration
Global Impression of Change
Self-report measure of perceived change in ADHD symptoms. This scale ranges from 1 to 7 with higher scores indicating greater improvements.
Time frame: 75 minutes post CBG/placebo administration
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