The Safety and Efficacy of Carotid Body Modulation Therapy in Hypertensive Patients by External Ultrasonic Micro-bubble

Inclusion Criteria: * Hypertensive patients for CB modulation therapy 1. Two or more antihypertensive medications that had been prescribed at least 50% of the manufacturer's maximum dose for at least 2 consecutive weeks before study; Patients take an angiotensin-converting enzyme inhibitor (ACEI) (or angiotensin-ⅱ receptor antagonist (ARB)) and calcium channel blocker (CCB) (or thiazide diuretic) ; Office systolic blood pressure (SBP)≥150 mmHg and \<180mmHg. 2.24-hour ambulatory systolic blood pressure: ≥135 mmHg and \<170 mmHg 3.A history of primary hypertension was recorded. 4.Patients who can understand the purpose of the trial, voluntarily participate and sign informed consent, and are willing to cooperate with clinical follow-up * Patients for CB Volume and activity evaluation Hypertension group 1. Primary hypertension patients agrees to take part in this study and perform CB MRI, ultrasound, CB activity tests and sign the informed consent. 2. The office blood pressure of patients ≥ 140/90 mmHg; the patents were diagnosed hypertension and are taking anti-hypertensive drugs could also include, although the office blood pressure \< 140/90 mmHg. 3. The CB could be detected by carotid ultrasound or MRI. Control group <!-- --> 1. The volunteers agree to take part in this study and perform CB MRI, ultrasound, CB activity tests and sign the informed consent. 2. The volunteers are healthy. Exclusion Criteria: * Hypertensive patients for CB modulation therapy 1. Carotid body anatomy is not eligible for treatment: ultrasound examination before treatment fail to find carotid body at carotid artery bifurcation. 2. Carotid body anatomical heterotopic is difficult to select or unsuitable for ultrasound irradiation. 3. Carotid anatomy that does not meet treatment conditions: severe carotid stenosis or occlusion. 4. Carotid ulcer. 5. Severe tortuosity of carotid artery 6. After carotid artery stenting or stripping 7. Other conditions that are not suitable for carotid intervention 8. Glomerular filtration rate (eGFR) \<45 mL/min / 1.73 m2 9. Have type 1 diabetes or poorly controlled type 2 diabetes (defined as plasma HbA1c≥ 9.0% or 24-hour urinary protein quantity \>1g/24h or proliferative retinal lesions) 10. postural hypotension. 11. Recent vascular events: Experienced acute myocardial infarction, unstable angina, syncope, or cerebrovascular accident within 3 months of the screening period. 12. Suspected secondary hypertension. 13. Respiratory support: The individual requires long-term oxygen support or mechanical ventilation (except for nighttime breathing support only because of sleep apnea). 14. Life expectancy \<1 year. 15. A woman who is pregnant, breastfeeding, or planning to become pregnant. 16. Subjects who are currently enrolled in another clinical trial and have not completed the primary endpoint. 17. Allergic to contrast media. 18. The investigators judged the patients' poor compliance and other reasons for not being suitable for participants in the trial. 19. Any other conditions that the investigator did not consider appropriate to participate in the trial. * Patients for CB Volume and activity evaluation 1. the CB could not be detected by carotid ultrasound or MRI. 2. The patients have secondary hypertension, heart failure. 3. The patients have type 1diabetes mellitus, CB tumor. 4. The patients were diagnosed as OSAS. 5. The patients have severe chronic constructive pulmonary disease, interstitial lung disease or other severe lung diseases. 6. Women who are pregnant, breastfeeding, or planning to become pregnant. 7. Patients with other conditions which are not appropriate for enrollment judged by the investigators.