A comprehensive perioperative nutrition management plan for pancreaticoduodenectomy, primarily based on pancreatic enzyme replacement therapy (PERT). A prospective randomized controlled study was conducted to comprehensively analyze the perioperative nutritional status of patients undergoing pancreaticoduodenectomy, with the aim of exploring: 1. The effect of PERT on postoperative complications and physiological status after pancreaticoduodenectomy; 2. The efficacy of PERT treatment on clinical symptoms, nutritional indicators, and quality of life (QOL) related to pancreatic exocrine dysfunction (PEI) after pancreaticoduodenectomy; 3. The personalized full process nutrition management strategies based on risk factor stratification.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
100
pancreatic enzyme replacement therapy
Routine treatment plan without PERT
Shanghai Ruijin Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGAbdominal Skeletal Muscle Index (SMI)
Measurement of abdominal skeletal muscle area at the third lumbar spine plane using abdominal plain scan CT and comparison of baseline level SMI change rate.
Time frame: 8 weeks post-operation
Postoperative complications
postoperative pancreatic fistula, delayed gastric emptying, postoperative hypoproteinemia;
Time frame: 8 weeks post-operation
Nutritional indicators
Patient generated subjective global assessment (PG-SGA);
Time frame: 8 weeks post-operation
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