Green coffee extract (GCE) supplementation has been shown to induce favourable health benefits on glucose metabolism and weight management. Previous literature suggests that the benefits of GCE are due to the high bioavailability of chlorogenic acid (CGA) which is known for its antioxidant and anti-inflammatory properties but is destroyed during the bean roasting process used to make coffee in Western societies. Whilst some studies examining chronic and high dose GCE supplementation (4-12 weeks) report beneficial effects on glucose metabolism and reductions in body mass following supplementation, comparably less is known about the effect of acute (single dose) GCE supplementation. Another natural compound, alpha-lipoic acid (ALA) has antioxidant properties and may also benefit glucose metabolism. The purpose of the current study is to determine the impact of acute supplementation of GCE with ALA on postprandial blood glucose concentration following consumption of a carbohydrate drink in healthy adults. A secondary objective is to evaluate the effect of GCE+ALA on blood insulin concentrations, insulin sensitivity, glucose oxidation, and perceptions of appetite.
The primary purpose of this study is to determine if GCE combined with ALA supplementation influences postprandial glucose metabolism. Participants will complete 3 visits to the investigator's laboratory at the University of Toronto. On each occasion, participants will consume a sugary drink (75g sugar) and investigators will take blood and breath samples for 2 hours. Participants will also be asked to fill out some questionnaires about appetite during this time. Thirty minutes before consuming the sugary drink, participants will consume one of the following pill supplements in a randomized order: 1) 200mg CGE + 200mg ALA; 2) 200mg GCE + 400mg ALA; or 3) Placebo (no CGE or ALA). The study will advance knowledge regarding the effects of GCE and ALA on postprandial glycemia and insulin sensitivity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
20
Participants will consume a pill containing 200mg green coffee extract and 200mg alpha-lipoic acid 30 minutes before a 75g oral glucose tolerance test
Participants will consume a pill containing 200mg green coffee extract and 400mg alpha-lipoic acid 30 minutes before a 75g oral glucose tolerance test
Participants will consume a placebo pill (500mg insoluble microcrystalline cellulose, 5mg magnesium stearate, 5mg silicon dioxide) prior to a 75g oral glucose tolerance test
Goldring Centre for High Performance Sport
Toronto, Ontario, Canada
Glucose incremental area under the curve
glucose incremental area under the curve measured during an oral glucose tolerance test
Time frame: 2 hours
Mean glucose concentration
Mean glucose concentration measured during an oral glucose tolerance test
Time frame: 2 hours
Insulin incremental area under the curve
insulin incremental area under the curve measured during an oral glucose tolerance test
Time frame: 2 hours
Mean insulin concentration
mean insulin concentration measured during an oral glucose tolerance test
Time frame: 2 hours
peak glucose concentration
peak glucose concentration measured during an oral glucose tolerance test
Time frame: 2 hours
peak insulin concentration
peak insulin concentration measured during an oral glucose tolerance test
Time frame: 2 hours
Postprandial glucose oxidation
Postprandial glucose oxidation measured with a metabolic tracer
Time frame: 2 hours
Appetite perceptions
Visual analog scales (0-100) will be used to determine perceptions of hunger, satisfaction, fullness, and prospective food consumption with higher scores denoting increased perceptions.
Time frame: 2 hours
Insulin sensitivity
insulin sensitivity measured via the Matsuda Index during an oral glucose tolerance test
Time frame: 2 hours
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