Febrile Illness in Guinea

Centre National de Formation et de Recherche en Sante Rurale2,500 enrolled

Overview

To date, the underlying causes of community-acquired fever, particularly non-malarial fever, are insufficiently documented in Guinea. Moreover, diagnostic capacity is limited, leading to inadequate prescription of antibiotics and antimalarials, as well as substantial delay in outbreak recognition. Thus, the investigators undertook a prospective observational multi-centric cohort study of febrile patients presenting at the emergency and outpatient department of selected health centers, districts and regional hospitals in four ecologically distinct sentinel health districts in Guinea.

Study Type

OBSERVATIONAL

Enrollment

2,500

Conditions

Febrile Illness

Eligibility

Sex: ALLMin age: 2 Months

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥2 months old * Documented fever (axillary temperature \>37.5°C) at presentation or fever reported within the prior 24 hours * Availability for follow-up for 21 days * Willingness and ability of the patient or culturally acceptable representative to give informed consent for participation in the study Exclusion Criteria: * History of hospitalization (for \> 48 hours within the last 14 days) at any health facility

Locations (1)

Centre National de Formation et de Recherche en Santé Rurale

Maférinya, Forécariah, Guinea

Outcomes

Primary Outcomes

Pattern of symptoms and laboratory results at presentation and during follow-up

Proportion will be estimated

Time frame: Day 0 and day 21

Syndromic and/or etiologic diagnoses as established at day 21

Proportion will be estimated

Time frame: Day 0

Pattern and duration of antibiotic use (and other treatments)

Proportion and mean or median will be estimated

Time frame: Day 0

Immediate or secondary hospital admissions and of secondary/unscheduled visits

Proportion will be estimated

Time frame: Day 0 and day 21

Participants alive (with or without symptoms) or dead at day 21.

Survival or mortality rate will be estimated

Time frame: Day 21

Secondary Outcomes

White blood cells and C-reactive protein levels at baseline and association with syndromic/etiologic diagnoses and with patient outcome at day 21

Mean or median level will be estimated

Time frame: Day 0

Association of seasonal, geographical, demographic, clinical and first-line laboratory variables (malaria RDT and smear, biochemistry) with presenting syndromes/main etiologies

OR or RR will be estimated as appropriate

Time frame: Day 0

Confirmed arboviral pathogens and identification of epidemiological/clinical/laboratory predictors

Proportions will be estimated

Time frame: Day 0

Cases fulfilling any of the case definitions of the 20 epidemic-prone infections under surveillance as compared to the final diagnosis and proportion of them timely reported to health authorities

Proportions will be estimated

Time frame: Day 0

Febrile Illness in Guinea

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts