Clinical Study of Taurine Combined With Sintilimab and Chemotherapy for Treatment of Advanced Gastric Cancer

Inclusion Criteria: 1. Age 18 or older, no gender limitation; 2. Pathologically confirmed gastric cancer or adenocarcinoma of the gastroesophageal junction, local lesions cannot be radically resected or metastatic gastric cancer; 3. Expected survival of ≥ 3 months; 4. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1; 5. At least one measurable lesion outside the stomach (RECIST 1.1); 6. Patients informed about the purpose and course of the study and provided a written consent to participate. Exclusion Criteria: 1. Use of taurine agent within 1 month prior to randomization on this study; 2. Patients received prior systemic therapy for gastric cancer; 3. Patients with operable gastric cancer; 4. Patients with positive HER-2 and willing to receive herceptin treatment; 5. Patients with gastrointestinal obstruction or active bleeding in the gastrointestinal tract, as well as perforation and dysphagia; 6. Patients with active autoimmune disease that has required systemic treatment in past 2 years; 7. Patients diagnosed as immunodeficiency or receiving systemic steroid therapy or any other form of immunosuppressive therapy; 8. Patients with severe heart, lung, liver, kidney, endocrine, hematopoietic system or psychiatric diseases were considered not suitable for the study group; 9. Patients with other medical conditions that interfere with the trial and are deemed unsuitable for inclusion in the trial by the investigator; 10. Other conditions that the investigator thinks are not suitable to participate in this clinical trial.